Biochemical and morphological changes in herniated human intervertebral disc
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MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration
2021, Biomedicine and PharmacotherapyCitation Excerpt :In addition to regulating ECM metabolism in the IVD, the MAPK/ERK pathway inhibits the apoptosis of IVD cells. Apoptosis has been proven to play a key role in the progression of IDD; the loss of IVD cells caused by excessive apoptosis has long been considered an important cause of reduced ECM synthesis during IDD [55–58]. Several reports have shown that the MAPK/ERK signaling pathway is involved in inflammation-induced apoptosis of NP cells, and its inhibition is considered a potential therapeutic target for the treatment of IDD [47].
Role of the Wnt pathway in the formation, development, and degeneration of intervertebral discs
2021, Pathology Research and PracticeCitation Excerpt :In addition to inhibiting cell proliferation, promoting cell apoptosis is also one of the main mechanisms by which Wnt signaling participates in IVDD. Excessive apoptosis of cells in the process of IVDD has always been considered a major cause of decreased ECM synthesis [100–102]. Chen collected NP tissues from patients with IVDD and lumbar fractures and found that the expression of Wnt and β-catenin increased in degenerative patients.
Therapeutic evaluation of acupoint stimulation with needle-scapelon on rat model of degenerative cervical intervertebral discs
2019, Biomedicine and PharmacotherapySubstrate stiffness and mechanical stress due to intercellular cooperativity guides tissue structure
2018, Journal of Theoretical BiologyCitation Excerpt :Interestingly, soft matrices also increase TGF-β induced apoptosis, whereas rigid matrices promote epithelial-mesenchymal transition (EMT) (Leight et al., 2012; Rahimi and Leof, 2007). Intervertebral disc (IVD) generation, one of the key processes that causes disc herniation, is triggered by profound apoptosis due to decreased rigidity of ECM (Ahsan et al., 2001). In spite of all these findings, characterization of evolving tissue pattern governed by the integral response of varying rigidity of the ECM and mechanochemical pathways is missing.
Inhibition of miR-96-5p alleviates intervertebral disc degeneration by regulating the peroxisome proliferator-activated receptor γ/nuclear factor-kappaB pathway
2023, Journal of Orthopaedic Surgery and Research
This paper was presented, in part, at the British and Japanese Orthopaedic Association Combined Congress, held in London on October 3–6, 2000.