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Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies

  • Biological Psychiatry - Rapid Communication
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Abstract

A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing ~500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability.

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Acknowledgments

We thank the patients for their support and participation. This study was supported by the DFG (KFO 125, SFB 581, SFB TRR 58, ME 1923/5-1, ME 1923/5-3), BMBF (IZKF 01KS9603), NIH Neuroscience Microarray Consortium (DHS) and the EC (NEWMOOD LSHM-CT-2003-503474). We greatly appreciate the support from all co-workers contributing to organization of the study, data management, and laboratory work.

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Correspondence to Klaus-Peter Lesch.

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Lesch, KP., Timmesfeld, N., Renner, T.J. et al. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. J Neural Transm 115, 1573–1585 (2008). https://doi.org/10.1007/s00702-008-0119-3

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