Abstract
Oxidative stress has been suggested to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer disease (AD) and Parkinson disease (PD). Heme oxygenase-1 (HO-1), a key enzyme in heme catabolism, also functions as an antioxidant enzyme. Here, we show that a (GT)n repeat in the human HO-1 gene promoter region is highly polymorphic, although no particular alleles are associated with AD or PD. This newly identified genetic marker should allow us to study the possible involvement of HO-1 in certain human diseases.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 5 November 1996 / Accepted: 18 February 1997
Rights and permissions
About this article
Cite this article
Kimpara, T., Takeda, A., Watanabe, K. et al. Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease. Hum Genet 100, 145–147 (1997). https://doi.org/10.1007/s004390050480
Issue Date:
DOI: https://doi.org/10.1007/s004390050480