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Linkage analysis with candidate genes: the Taiwan young-onset hypertension genetic study

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Abstract.

A genetic linkage study of young-onset hypertension was performed on data from 59 nucleus families of Han Chinese residing in Taiwan. Thirty seven microsatellite markers near 18 hypertension candidate genes were genotyped. In a nonparametric identity-by-descent sibpair analysis, a positive linkage signal (defined as P<0.05) was found for four microsatellite markers, viz., D1S1612 (P=0.0162), D1S547 (P=0.0263), D8S1145 (P=0.0284), and D17S2193 (P=0.0256), which were located near genes for atrial natriuretic peptide (NPPA)/glucose transporter 5 (SLC2A5), angiotensinogen (AGT), lipoprotein lipase (LPL), and angiotensin-conveting enzyme (DCP1), respectively. Marker D5S1480 located near beta-2-adrenergic receptor (ADRB2) had a borderline P value (P=0.0785) for the positive signal. Comprehensive genotyping with further markers in these regions is underway to confirm whether these genes are linked to young-onset hypertension.

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Authors and Affiliations

  1. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, , , , ,

    Wen-Harn Pan, Cathy Fann & Sheng-Yeu Wu

  2. Department of Cardiology, Taipei Veterans General Hospital, Taipei, Taiwan, , , , ,

    Jaw-Wen Chen

  3. Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei, Taiwan, , , , ,

    Yuh-Shan Jou

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  1. Wen-Harn Pan
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  2. Jaw-Wen Chen
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  3. Cathy Fann
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  4. Yuh-Shan Jou
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  5. Sheng-Yeu Wu
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Pan, WH., Chen, JW., Fann, C. et al. Linkage analysis with candidate genes: the Taiwan young-onset hypertension genetic study. Hum Genet 107, 210–215 (2000). https://doi.org/10.1007/s004390000365

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  • DOI: https://doi.org/10.1007/s004390000365

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