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A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis

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Abstract

Allergic rhinitis is a major public health problem and has seen its prevalence increase during the past few decades. Interleukin 13 (IL-13) has been implicated in the pathogenesis and in the regulation of immunoglobulin E (IgE) production. Single nucleotide polymorphisms (SNPs) have been found in both the coding sequence and the promoter region of IL-13, and such SNPs have been associated with allergic asthma. We have investigated whether IL-13 SNPs are associated with allergic rhinitis. Among 188 Chinese adult patients with allergic rhinitis and 87 normal controls, no significant difference was found in either allele or haplotype frequency of the SNPs between the two groups. Within patients, there was a significant association of the IL-13 Arg130Gln SNP, but not of the IL-13 promoter −1112(C/T) SNP, with serum total IgE levels. Patients with a Gln/Gln genotype showed much higher serum total IgE than those with an Arg/Arg genotype. When tested for serum-specific IgE, patients allergic to Derp 1, but not those allergic to Artemisia pollen, showed a significant association with the IL-13 promoter SNP. Thus, our results suggest a possible involvement of IL-13 SNPs in the regulation of IgE production in response to allergens in this Chinese population.

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References

  • Arima K, Umeshita-Suyama R, Sakata Y, Akaiwa M, Mao XQ, Enomoto T, Dake Y, Shimazu S, Yamashita T, Sugawara N, Brodeur S, Geha R, Puri RK, Sayegh MH, Adra CN, Hamasaki N, Hopkin JM, Shirakawa T, Izuhara K (2002) Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma. J Allergy Clin Immunol 109:980–987

    Article  CAS  PubMed  Google Scholar 

  • Benson M, Adner M, Cardell LO (2001) Cytokines and cytokine receptors in allergic rhinitis: how do they relate to the Th2 hypothesis in allergy? Clin Exp Allergy 31:361–367

    Article  CAS  PubMed  Google Scholar 

  • Bousquet J, Van Cauwenberge P, Khaltaev N (2001) Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 108: S147–S334

    Article  CAS  PubMed  Google Scholar 

  • Celedon JC, Soto-Quiros ME, Palmer LJ, Senter J, Mosley J, Silverman EK, Weiss ST (2002) Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica. Clin Exp Allergy 32: 387–390

    Article  CAS  PubMed  Google Scholar 

  • DeMeo DL, Lange C, Silverman EK, Senter JM, Drazen JM, Barth MJ, Laird N, Weiss ST (2002) Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol 23: 335–348

    Article  CAS  PubMed  Google Scholar 

  • Graves PE, Kabesch M, Halonen M, Holberg CJ, Baldini M, Fritzsch C, Weiland SK, Erickson RP, Mutius E von, Martinez FD (2000) A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol 105:506–513

    CAS  PubMed  Google Scholar 

  • Heinzmann A, Mao XQ, Akaiwa M, Kreomer RT, Gao PS, Ohshima K, Umeshita R, Abe Y, Braun S, Yamashita T, Roberts MH, Sugimoto R, Arima K, Arinobu Y, Yu B, Kruse S, Enomoto T, Dake Y, Kawai M, Shimazu S, Sasaki S, Adra CN, Kitaichi M, Inoue H, Yamauchi K, Tomichi N, Kurimoto F, Hamasaki N, Hopkin JM, Izuhara K, Shirakawa T, Deichmann KA (2000) Genetic variants of IL-13 signalling and human asthma and atopy. Hum Mol Genet 9:549–559

    Google Scholar 

  • Howard TD, Whittaker PA, Zaiman AL, Koppelman GH, Xu J, Hanley MT, Meyers DA, Postma DS, Bleecker ER (2001) Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. Am J Respir Cell Mol Biol 25:377–384

    CAS  PubMed  Google Scholar 

  • Kruglyak L, Nickerson DA (2001) Variation is the spice of life. Nat Genet 27:234–236

    Article  CAS  PubMed  Google Scholar 

  • Leung DY (1998) Molecular basis of allergic diseases. Mol Genet Metab 63:157–167

    CAS  PubMed  Google Scholar 

  • Leung TF, Tang NL, Chan IH, Li AM, Ha G, Lam CW (2001) A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children. Clin Exp Allergy 31:1515–1521

    Article  CAS  PubMed  Google Scholar 

  • Liu X, Nickel R, Beyer K, Wahn U, Ehrlich E, Freidhoff LR, Bjorksten B, Beaty TH, Huang SK (2000) An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90). J Allergy Clin Immunol 106:167–170

    CAS  PubMed  Google Scholar 

  • Lundback B (1998) Epidemiology of rhinitis and asthma. Clin Exp Allergy 28 (Suppl 2):3–10

  • Pawankar RU, Okuda M, Hasegawa S, Suzuki K, Yssel H, Okubo K, Okumura K, Ra C (1995) Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis. Am J Respir Crit Care Med 152:2059–2067

    CAS  PubMed  Google Scholar 

  • Pouw Kraan TC van der, Veen A van, Boeije LC, Tuyl SA van, Groot ER de, Stapel SO, Bakker A, Verweij CL, Aarden LA, Zee JS van der (1999) An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun 1:61–65

    Article  PubMed  Google Scholar 

  • Tsunemi Y, Saeki H, Nakamura K, Sekiya T, Hirai K, Kakinuma T, Fujita H, Asano N, Tanida Y, Wakugawa M, Torii H, Tamaki K (2002) Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients. J Dermatol Sci 30:100–107

    Article  CAS  PubMed  Google Scholar 

  • Vercelli D (2002) Genetics of IL-13 and functional relevance of IL-13 variants. Curr Opin Allergy Clin Immunol 2:389–393

    PubMed  Google Scholar 

  • Wills-Karp M (2001) IL-12/IL-13 axis in allergic asthma. J Allergy Clin Immunol 107:9-18

    Article  PubMed  Google Scholar 

  • Wills-Karp M, Chiaramonte M (2003) Interleukin-13 in asthma. Curr Opin Pulm Med 9:21–27

    Article  PubMed  Google Scholar 

  • Xing Z, Yu D (2001) Linkage of allergic rhinitis with HLA-DRB alleles polymorphism. Lin Chuang Er Bi Yan Hou Ke Za Zhi 15:199–201

    CAS  PubMed  Google Scholar 

  • Zeiger RS, Heller S (1993) Development of nasal basophilic cells and nasal eosinophils from age 4 months through 4 years in children of atopic parents. J Allergy Clin Immunol 91:723–734

    CAS  PubMed  Google Scholar 

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Acknowledgements

This study was supported by the 985 Scientific Foundation of Peking University Medical Center for Human Disease Genomics (grant no. 2001-5). There is no conflict of interest in the paper.

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Correspondence to Li-Sheng Yu.

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M. Wang and Z.-M. Xing should be considered as equal first authors

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Wang, M., Xing, ZM., Lu, C. et al. A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis. Hum Genet 113, 387–390 (2003). https://doi.org/10.1007/s00439-003-1001-x

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  • DOI: https://doi.org/10.1007/s00439-003-1001-x

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