Abstract
The last 5 years have seen rapid progress in Parkinson’s disease (PD) genetics, with the publication of a series of large-scale genome wide association studies for PD, and evaluation of the roles of the LRRK2 and GBA genes in the aetiology of PD. We are beginning to develop a coherent picture of the interplay of Mendelian and non-Mendelian factors in PD. Pathways involved in mitochondrial quality control (mitophagy), lysosomal function and immune function are emerging as important in the pathogenesis of PD. These pathways represent a target for therapeutic intervention and a way in which the heterogeneity of disease cause, as well as disease mechanism, can be established. In the future, there is likely to be an individualised basis for the treatment of PD, linked to the identification of specific genetic factors.
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Our work is funded by Parkinson’s UK (Grants 8047 and J-1101) and the Medical Research Council UK (G0700943, G1100643).
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On behalf of all authors, the corresponding author states that there is no conflict of interest.
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Lubbe, S., Morris, H.R. Recent advances in Parkinson’s disease genetics. J Neurol 261, 259–266 (2014). https://doi.org/10.1007/s00415-013-7003-2
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DOI: https://doi.org/10.1007/s00415-013-7003-2