Abstract
The etiology of hypoplastic left heart syndrome (HLHS) remains unclear. Since a genetic cause for HLHS has not been obvious, it is generally considered to be inherited in a multifactorial manner. Studies of twins are valuable in elucidating the genetic contribution to a birth defect such as HLHS. We report a case of monochorionic twins in whom one has HLHS and the other has a bicuspid aortic valve. Predisposing genetic and environmental influences on individuals with identical genotypes, such as twins, may result in discordance of left-sided flow lesions.
Similar content being viewed by others
References
RE Andrews AC Cook RWM Yates (2003) ArticleTitleConcordance for hypoplastic left heart syndrome in a monochorionic twin pregnancy Heart 89 e13 Occurrence Handle10.1136/heart.89.4.e13 Occurrence Handle1:STN:280:DC%2BD3s7isFKlsg%3D%3D Occurrence Handle12639890
DW Benson (2002) ArticleTitleThe genetics of congenital heart disease: a point in the revolution Cardiol Clin 20 385–394 Occurrence Handle10.1016/S0733-8651(02)00009-7 Occurrence Handle12371007
JA Bougbman KA Berg JA Astemborski EB Clark RJ Mc- Carter (1987) ArticleTitleFamilial risks of congenital heart defect assessed in a population-based epidemiologic study Am J Med Genet 26 839–849
JI Brenner KA Berg DS Schneider EB Clark JA Boughman (1989) ArticleTitleCardiac malformations in relatives of infants with hypoplastic left-heart syndrome Am J Dis Child 143 1492–1494 Occurrence Handle1:STN:280:By%2BD2s7pslE%3D Occurrence Handle2589285
BR Davies T Rizo A Arroyo-Valerio (2002) ArticleTitleCongenital heart disease and its association with other congenital malformations found at autopsy Pediatr Pathol Mol Med 21 541–549 Occurrence Handle10.1080/15227950290112798 Occurrence Handle12537771
JH Edwards (1986) ArticleTitleThe simulation of Mendelism Acta Genet 10 63–70
C Ferencz JD Rubin RF McCarter et al. (1985) ArticleTitleCongenital heart disease; prevalence at live birth: the Baltimore–Washington Infant Study Am J Epidemiol 121 31–36 Occurrence Handle1:STN:280:BiqD28bks1E%3D Occurrence Handle3964990
W Grobman E Pergament (1996) ArticleTitleIsolated hypoplastic left heart syndrome in three siblings Obsetet Gynecol 88 673–675 Occurrence Handle1:STN:280:BymH3sfptFc%3D
PD Grossfeld (1999) ArticleTitleThe genetics of hypoplastic left heart syndrome Cardiol Young 9 627–632 Occurrence Handle1:STN:280:DC%2BD3c%2FlvVymsw%3D%3D Occurrence Handle10593278
J Guenthard E Buehler E Jaeggi F Wyler (1994) ArticleTitlePossible genes for left heart formation on 11q23.3 Ann Genet 37 143–146 Occurrence Handle1:STN:280:ByqC2M%2Fks1E%3D Occurrence Handle7847796
H Kojima Y Ogimi K Mizutani Y Nishimura (1969) ArticleTitleHypoplastic left heart syndrome in siblings Lancet 2 701 Occurrence Handle1:STN:280:CCaB1c3gt1M%3D Occurrence Handle4185446
A Rosenthal (1996) ArticleTitlePhysiology, diagnosis, and clinical profile of the hypoplastic left heart syndrome Prog Pediatr Cardiol 5 19–22 Occurrence Handle10.1016/1058-9813(95)00145-X
JA Towbin J Belmont (2000) ArticleTitleMolecular determinants of left and right outflow tract obstruction Am J Med Genet 97 297–303 Occurrence Handle10.1002/1096-8628(200024)97:4<297::AID-AJMG1280>3.0.CO;2-O Occurrence Handle1:STN:280:DC%2BD3M3ps1ChsA%3D%3D Occurrence Handle11376441
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mu, T.S., McAdams, R.M. & Bush, D.M. A Case of Hypoplastic Left Heart Syndrome and Bicuspid Aortic Valve in Monochorionic Twins. Pediatr Cardiol 26, 884–885 (2005). https://doi.org/10.1007/s00246-005-1016-2
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00246-005-1016-2