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A Case of Hypoplastic Left Heart Syndrome and Bicuspid Aortic Valve in Monochorionic Twins

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Abstract

The etiology of hypoplastic left heart syndrome (HLHS) remains unclear. Since a genetic cause for HLHS has not been obvious, it is generally considered to be inherited in a multifactorial manner. Studies of twins are valuable in elucidating the genetic contribution to a birth defect such as HLHS. We report a case of monochorionic twins in whom one has HLHS and the other has a bicuspid aortic valve. Predisposing genetic and environmental influences on individuals with identical genotypes, such as twins, may result in discordance of left-sided flow lesions.

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Correspondence to T. S. Mu.

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Mu, T.S., McAdams, R.M. & Bush, D.M. A Case of Hypoplastic Left Heart Syndrome and Bicuspid Aortic Valve in Monochorionic Twins. Pediatr Cardiol 26, 884–885 (2005). https://doi.org/10.1007/s00246-005-1016-2

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