Abstract
We describe a polymorphic microsatellite in intron 38 of the neurofibromatosis type 1 (NF1) gene. The microsatellite consists of a CA/GT dinucleotide repeat detecting 8 alleles; it has a heterozygosity of 82 %.
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Barker D, Wright E, Nguyen K, Cannon L, Fain P, Golar D, Bishop DT, Carey JC, Baty B, Kivlin J, Willard H, Waye JS, Greig G, Leinwand L, Nakamura Y, O'Connell P, Leppert M, Lalouel JM, White R, Skolnick M (1987) Gene for von Recklinghausen neurofibromatosis in the pericentromeric region of chromosome 17. Science 236:1100–1102
Cawthon RM, Weiss R, Xu G, Viskochil D, Culver M, Stevens J, Robertson M, Dunn D, Gesteland R, O'Connell P, White R (1990) A major segment of the neurofirbromatosis type 1 gene: cDNA sequence, genomic structure and point mutations. Cell 62:193–201
O'Connell P, Viskochil D, Buchberg AM, Fountain J, Cawthon RM, Culver M, Stevens J, Rich DC, Ledbetter DH, Wallace M, Carey JC, Jenkins NA, Copeland NG, Collins FS, White R (1990) The human homolog of murineEvi-2 lies between two von Recklinghausen neurofibromatosis translocations. Genomics 7:547–554
Wallace MR, Marchuk A, Andersen LB, Letcher R, Odeh HM, Saulino AM, Fountain JW, Brereton A, Nicholson J, Mitchell AL, Brownstein BH, Collins FS (1990) Type 1 neurofibromato-sis gene: identification of a large transcript disrupted in three NF1 patients. Science 249:181–186
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Lázaro, C., Gaona, A., Xu, G. et al. A highly informative CA/GT repeat polymorphism in intron 38 of the human neurofibromatosis type 1 (NF1) gene. Hum Genet 92, 429–430 (1993). https://doi.org/10.1007/BF01247353
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DOI: https://doi.org/10.1007/BF01247353