Abstract
Abnormalities of neural crest development may be manifested in a wide variety of ways ranging from von Recklinghausen's disease to Sipple's syndrome — pheochromocytoma and medullary thyroid carcinoma. We report here yet another manifestation — coexistent multiple neuroblastomas and Hirschsprung's disease in a newborn. In a review of the English literature we have found the combination of neuroblastoma and Hirschsprung's disease recorded only once previously [2]. However, the relationship between the two diseases was not discussed. The two diseases may be at the extremes of a spectrum of neural crest developmental pathology, i. e., Hirschsprung's representing a deficiency and neuroblastoma representing malignant proliferation of cells of neural crest origin.
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Gaisie, G., Oh, K.S. & Young, L.W. Coexistent neuroblastoma and Hirschsprung's disease —Another manifestation of the neurocristopathy?. Pediatr Radiol 8, 161–163 (1979). https://doi.org/10.1007/BF00973826
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DOI: https://doi.org/10.1007/BF00973826