Summary
The neuropathological findings in two cases of Wolf-Hirschhorn syndrome (loss of the short arm of chromosome four) are dissussed and the literature is reviewed. Frequent abnormalities in this syndrome include decreased brain size, defects of gyration, heterotopias, dysplasias of nuclear structures, and disorganization of the callosal system.
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References
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Gottfried, M., Lavine, L. & Roessmann, U. Neuropathological findings in Wolf-Hirschhorn (4p-) syndrome. Acta Neuropathol 55, 163–165 (1981). https://doi.org/10.1007/BF00699242
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DOI: https://doi.org/10.1007/BF00699242