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Effect of clonidine on sleep patterns in man

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Summary

Clonidine (300 µg orally) increased in man the total duration of sleep and strikingly reduced the duration of REM sleep. Yohimbine (10 mg per os) did not alter the sleep patterns in man but antagonized the effects of clonidine. These results provide evidence that an α sympathomimetic mechanism could suppress REM sleep and increased the total duration of sleep.

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References

  • Andén, N.E., Corrodi, H., Fuxe, K., Hökfelt, B., Hökfelt, T., Rydin, C., Svensson, T.: Evidence for a central noradrenaline receptor stimulation by clonidine. Life Sci.9, 513 (1970)

    Google Scholar 

  • Andén, N.E., Grabowska, M., Strombom, U.: Different alpha-adrenoceptors in the central nervous system mediating biochemical and functional effects of clonidine and α-receptors blocking agents. Arch. Pharmacol.292, 43 (1976)

    Google Scholar 

  • Autret, A., Minz, M., Bussel, B., Cathala, H.P., Castaigne, P.: Human sleep and 5-HT. Effects of repeated high doses and of association with benserazide (Ro 04 4602). EEG. Clin. Neurophysiol.41, 408 (1976)

    Google Scholar 

  • Bock, K.D., Merguet, P., Murata, T., Heimsoth, V.: Klinisch-experimentelle Untersuchungen über die Wirkungen von Dichlorophenylaminoimidazolin. Hochdrucktherapie. Symposium über Clonidine (L. Heilmeyer, H.J. Holtmeier, E.F. Pfeiffer) p. 28. Stuttgart: Georg Thieme Verlag, 1968

    Google Scholar 

  • Bolme, P., Corrodi, H., Fuxe, K., Hökfelt, T., Lidbrinck, P., Goldstein, M.: Possible involvement of central adrenaline neurons in vasomotor and respiratory control. Studies with clonidine and its interactions with piperoxan and yohimbine. Europ. J. Pharmacol.28, 89 (1974)

    Google Scholar 

  • Delbarre, B., Schmitt, H.: Sedative effect of α-sympathomimetic drugs and their antagonism by adrenergic and cholinergic blocking drugs. Europ. J. Pharmacol.13, 356–363 (1971)

    Google Scholar 

  • Finch, L., Haeusler, G.: Further evidence for a central hypotensive action of α-methyldopa in both cat and rat. Brit. J. Pharmacol.47, 217 (1973)

    Google Scholar 

  • Florio, V., Bianchi, L. and Longo, V.G.: A study of the central effects of sympathomimetic drugs: EEG and behavioural investigations on clonidine and naphazoline. Neuropharmacol.14, 707 (1975)

    Google Scholar 

  • Gogolak, G., Stumpf, C.: Wirkung von 2-(2,6-Dichlorophenylethylamino)2-Imidazolin hydrochloride auf die EEG Weckreaktion beim Kaninchen. Arzneimittelforsch.16, 1050 (1966)

    Google Scholar 

  • Hökfelt, T., Fuxe, K., Goldstein, M. and Jahansson, O.: Evidence for adrenaline neurons in the rat brain. Acta physiol. scand.89, 286 (1973)

    Google Scholar 

  • Holman, R.B., Shillito, E.E., Vogt, V.I.: Sleep produced by clonidine (2-(2,6-dichlorophenylamino 2-imidazoline hydrochloride). Brit. J. Pharmacol.43, 685 (1971)

    Google Scholar 

  • Holman, R.B., Elliot, G.R., Barchas, J.D.: Neuroregulators and sleep mechanisms. Ann. Rev. Med.26, 499 (1975)

    Google Scholar 

  • Jouvet, M.: The role of monoamines and acetylcholine containing neurons in the regulation on sleep-waking cycle. Ergeb. Physiol.64, 165 (1972)

    Google Scholar 

  • Kleinlogel, H., Scholtysik, C., Sayers, A.C.: Effects of clonidine and BS 100–141 on the EEG sleep pattern in rat. Europ. J. Pharmacol.33, 159 (1975)

    Google Scholar 

  • Marley, E., Nistico, G.: Effects of catecholamines and adenosine derivates given into the brain of fowls. Brit. J. Pharmacol.46, 619 (1972)

    Google Scholar 

  • Marley, E., Nistico, G.: Central effects of clonidine 2-(2,6-dichlorophenylamino) 2-imidazoline hydrochloride in fowls. Brit. J. Pharmacol.55, 459 (1975)

    Google Scholar 

  • Matsuda, Y.: Effects of some sympathomimetic amines administered intraventricularly on rabbits EEG. Jap. J. Pharmacol.19, 102–169 (1969)

    Google Scholar 

  • Rechtschaffen, A., Kale, A.: A manual of standardized terminology techniques and scoring system for sleep stages of human subjects. Ed. National Institutes of Health Publication no 204 Bethesda, MD, USA, 1968

  • Schmitt, H.: Actions des alpha-sympathomimétiques sur les structures nerveuses. Actual. pharmacol.24, pp. 93–131 (1971)

    Google Scholar 

  • Schwartz, O.: Méthodes statistiques á l'usage des médecins et des biologistes. pp. 191–205. Paris: Flammarion 1963

    Google Scholar 

  • Starke, K., Montel, H., Endo, T., Taube, H.D.: Pharmacological consequences of the presynaptic control on noradrenaline release. in: Recent Advances in Hypertension: Vol. 2 (Ed. P. Milliez, M. Safar) p. 75. Reims France: Société Aliéna 1975

    Google Scholar 

  • Svensson, T.H., Bunny, B.S., Aghajanian, G.K.: Inhibition of both noradrenergic and serotoninergic neurons in brain by the adrenergic agonist clonidine. Brain Res.92, 291 (1975)

    Google Scholar 

  • Tran Quang Loc, Tsoucaris-Kupfer, D., Bogaievsky, Y., Bogaievsky, D., Delbarre, B., Schmitt, H.: Antagonisme de l'action sédative de la clonidine par quelques adrénolytiques. J. Pharmacol. (Paris),5, 51 (1974)

    Google Scholar 

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Autret, A., Minz, M., Beillevaire, T. et al. Effect of clonidine on sleep patterns in man. Eur J Clin Pharmacol 12, 319–322 (1977). https://doi.org/10.1007/BF00562444

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  • DOI: https://doi.org/10.1007/BF00562444

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