Summary
Clonidine (300 µg orally) increased in man the total duration of sleep and strikingly reduced the duration of REM sleep. Yohimbine (10 mg per os) did not alter the sleep patterns in man but antagonized the effects of clonidine. These results provide evidence that an α sympathomimetic mechanism could suppress REM sleep and increased the total duration of sleep.
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Autret, A., Minz, M., Beillevaire, T. et al. Effect of clonidine on sleep patterns in man. Eur J Clin Pharmacol 12, 319–322 (1977). https://doi.org/10.1007/BF00562444
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DOI: https://doi.org/10.1007/BF00562444