Abstract
Three models of codon fixation variability are formulated. The first assumes that all codons have the same fixation rate. The second assumes that some codons are invariant and that all variable codons have the same fixation rate. The third assumes that some codons are invariant and that the variable codons comprise two classes, all members of each class having the same fixation rate. Maximum likelihood estimates of the parameters and tests of goodness-of-fit are given for each model.
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References
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Paper number 1383 from the Laboratory of Genetics. Work performed in part at the University of Iowa, Department of Preventive Medicine and Environmental Health and Department of Statistics, Iowa City, Iowa. Computing supported by the Graduate College, University of Iowa.
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Markowitz, E. Estimation and testing goodness-of-fit for some models of codon fixation variability. Biochem Genet 4, 595–601 (1970). https://doi.org/10.1007/BF00486097
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DOI: https://doi.org/10.1007/BF00486097