Abstract
DNA methylation at the promoter region of X-linked genes is associated with the maintenance of X inactivation in mammals. One of the methylated DNA binding proteins, MECP2, that binds to methylated bases in DNA is encoded by a gene (Mecp2) located on the mouse X Chromosome (Chr). To determine whether this gene was expressed from the inactive X Chr, and X-autosome translocation (T(X;16)16H) system in which expression from the Mecp2 allele on the inactive X Chr could be assayed was used. Results from these experiments indicate that Mecp2 is subject to X inactivation in mouse.
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Adler, D.A., Quaderi, N.A., Brown, S.D.M. et al. The X-linked methylated DNA binding protein, Mecp2, is subject to X inactivation in the mouse. Mammalian Genome 6, 491–492 (1995). https://doi.org/10.1007/BF00356163
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DOI: https://doi.org/10.1007/BF00356163