Summary
Data from a cytogenetic survey of spontaneous abortions were examined to determine the incidence and origin of mosaic trisomies in this population. The overall frequency of mosaicism among trisomies was approximately 5%, but the level of mosaicism varied significantly among trisomies, being much higher for the nonacrocentric than for the acrocentric trisomies. Evidence from chromosome heteromorphism analysis suggests that the extra chromosome in mosaic trisomies usually has a meiotic origin.
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This work was supported by Grant HD 07879 and Fellowship HD 05576 from the National Institutes of Health
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Hassold, T. Mosaic trisomies in human spontaneous abortions. Hum Genet 61, 31–35 (1982). https://doi.org/10.1007/BF00291327
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DOI: https://doi.org/10.1007/BF00291327