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The TRPV4 Channel

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Book cover Mammalian Transient Receptor Potential (TRP) Cation Channels

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 222))

Abstract

The widely distributed TRPV4 cationic channel participates in the transduction of both physical (osmotic, mechanical, and heat) and chemical (endogenous, plant-derived, and synthetic ligands) stimuli. In this chapter we will review TRPV4 expression, biophysics, structure, regulation, and interacting partners as well as physiological and pathological insights obtained in TRPV4 animal models and human genetic studies.

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Acknowledgments

Work at the authors’ laboratory is supported by the Spanish Ministry of Economy and Competitiveness (SAF2012-38140, SAF2010-16725), Fondo de Investigación Sanitaria (Red de Investigación Cardiovascular RD12/0042/0014), Fondos Europeos de Desarrollo Regional (FEDER), and Generalitat de Catalunya (SGR05-266). M.A.V. is the recipient of an ICREA Academia Award.

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Authors and Affiliations

  1. Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain

    Anna Garcia-Elias, Sanela Mrkonjić, Carole Jung, Carlos Pardo-Pastor, Rubén Vicente & Miguel A. Valverde

  2. Laboratory of Molecular Physiology, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Room 343, C/ Dr. Aiguader 88, Barcelona, 08003, Spain

    Miguel A. Valverde

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  1. Anna Garcia-Elias
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  2. Sanela Mrkonjić
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  3. Carole Jung
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  4. Carlos Pardo-Pastor
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  5. Rubén Vicente
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  6. Miguel A. Valverde
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Correspondence to Miguel A. Valverde .

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  1. Laboratory Ion Channel Research Campus Gasthuisberg, KU Leuven Department Cell Mol Medicin, Leuven, Belgium

    Bernd Nilius

  2. Institut für Experimentelle u. Klinische, Pharmakologie und Toxikologie, Universität des Saarlandes, Homburg, Saarland, Germany

    Veit Flockerzi

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Garcia-Elias, A., Mrkonjić, S., Jung, C., Pardo-Pastor, C., Vicente, R., Valverde, M.A. (2014). The TRPV4 Channel. In: Nilius, B., Flockerzi, V. (eds) Mammalian Transient Receptor Potential (TRP) Cation Channels. Handbook of Experimental Pharmacology, vol 222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54215-2_12

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