Regular ArticleOncogene amplification in solid tumors☆
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Small nucleolar RNAs in cancer
2012, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :For instance, snoRD33 is located at chromosome 19q13.3 that contains potential oncogenes involved in malignancies, including lung cancer [58,59], whereas snoRD66 and snoRD76 are located at chromosomal regions 3q27.1 and 1q25.1, respectively. 3q27.1 and 1q25.1 are two of the most frequently amplified chromosomal segments in human solid tumors [59–63]. Recently, Gee et al. used four snoRNAs, RNU44, RNU48, RNU43 and RNU6B, as internal control genes to analyze cancer-related miRNAs in two patient series: 219 breast cancer and 46 head and neck squamous cell carcinomas [64].
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