Regular ArticleAltered Folate Metabolism and Disposition in Mothers Affected by a Spina Bifida Pregnancy: Influence of 677c → t Methylenetetrahydrofolate Reductase and 2756a → g Methionine Synthase Genotypes
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Cited by (45)
Folate and microRNA: Bidirectional interactions
2017, Clinica Chimica ActaCitation Excerpt :miRNA may also impact folate dependent pathways important in development via modulation of expression enzymes involved in folate mediated 1CM, with consequences for folate dependent outcomes, independent of a deficiency of intake. Polymorphisms in these genes alter the risk of neural tube defects and other developmental and reproductive abnormalities [39]. These polymorphisms may alter the binding and function of miRNA, modulating their effects.
Association between the methionine synthase A2756G polymorphism and neural tube defect risk: A meta-analysis
2013, GeneCitation Excerpt :A2756G (rs1805087), a common polymorphism in MTR gene which converts aspartic acid to glycine (Leclerc et al., 1998), has been demonstrated to contribute to alterations in plasma levels of homocysteine and folate (Harmon et al., 1999; Lucock et al., 2000; Morrison et al., 1997; Wang et al., 1999). To date, the association between the MTR A2756G polymorphism and NTD risk has been evaluated in several studies(Akar et al., 2000; Alfarra, 2010; Brody et al., 1999; Candito et al., 2008; Christensen et al., 1999; De Marco et al., 2002; Gos et al., 2004; Gueant-Rodriguez et al., 2003; Johanning et al., 2000; Lucock et al., 2000; Morrison et al., 1998; Shaw et al., 1999, 2009; van der Put et al., 1997; Zhu et al., 2003), but the results remain inconsistent, making it hard to clarify the nature of the MTR A2756G polymorphism's contribution to NTD risk. For genetic association case–control studies that check candidate polymorphisms, sample size is an important influencing factor for study accuracy.
Association between MTR A2756G and MTRR A66G polymorphisms and maternal risk for neural tube defects: A meta-analysis
2013, GeneCitation Excerpt :Initially, van der Put et al. (1997a) and Morrison et al. (1998) failed to demonstrate a significant association between A2756G polymorphism and maternal risk for NTDs in Netherlands and UK populations respectively. Subsequently, some studies (Candito et al., 2008; Christensen et al., 1999; De Marco et al., 2002; Doolin et al., 2002; Gos et al., 2004; Johanning et al., 2000; Lucock et al., 2000; O'Leary et al., 2005; Zhu et al., 2003) suggested that maternal A2756G polymorphism has no risk of having an NTD baby in European and Hispanic–American populations. However, Doolin et al. (2002) used a transmission disequilibrium test to demonstrate that A2756G polymorphism affects the risk of spina bifida via the maternal rather than the embryonic genotype in the American population.
Vitamin B<inf>12</inf> and birth defects
2009, Molecular Genetics and MetabolismSyndromes, disorders and maternal risk factors associated with neural tube defects (IV)
2008, Taiwanese Journal of Obstetrics and GynecologyMTHFR C677T and MTR A2756G gene polymorphism in neural tube defect patients and its association with red blood cell folate level in Eastern Indian Population
2022, Journal of Indian Association of Pediatric Surgeons
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