Elsevier

Genomics

Volume 74, Issue 1, 15 May 2001, Pages 36-44
Genomics

Regular Article
Identification of the Human KIF13A Gene Homologous to Drosophila kinesin-73 and Candidate for Schizophrenia

https://doi.org/10.1006/geno.2001.6535Get rights and content

Abstract

Several studies have reported significant linkage for schizophrenia on 6p23, with a maximum lod score between D6S274 and D6S285. In this paper, we present a new human kinesin gene localized in this 2-cM interval. This gene, termed KIF13A, belongs to the unc-104/KIF1A kinesin subfamily and represents the orthologue of Drosophila kinesin-73. Several alternative transcripts are differentially expressed in human tissues, probably reflecting differences in cargo binding and transport of corresponding proteins. During early mouse development, its homologue (Kif13A) is expressed essentially in the central nervous system. In Caenorhabditis elegans, the unc-104 gene is involved in axonal anterograde transport, and null mutants present several behavioral defects. The putative function and genomic localization of KIF13A make this gene an interesting candidate for genetic predisposition to schizophrenia. We provide sequences of 20 single-nucleotide polymorphisms localized within KIF13A to test for association studies between this gene and schizophrenia.

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    Sequence data from this article have been deposited with the EMBL Data Library under Accession Nos. AJ291578 and AJ291579.

    1

    To whom correspondence should be addressed at the Laboratoire d'Immunogénétique Humaine, INSERM E021, Institut Pasteur, 25, Rue du Docteur Roux, 75724 Paris Cedex 15, France. Telephone: (33) 1 40 61 32 16. Fax: (33) 1 40 61 31 53. E-mail: [email protected].

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