Regular ArticleIdentification of the Human KIF13A Gene Homologous to Drosophila kinesin-73 and Candidate for Schizophrenia☆
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Genes underlying genetic correlation between growth, reproductive and parasite burden traits in beef cattle
2021, Livestock ScienceCitation Excerpt :Two FCGs (KIF13A and TPMT) associated with a growth trait (BW) and a parasite burden trait (EIM) were found in chromosome 23. The KIF13A gene (Kinesin-like protein) is highly expressed in all regions of the central nervous system and its transcripts are present in several tissues, with a higher expression in the pancreas, kidneys and placenta (Jamain et al., 2001). In a study with buffalos, it was suggested that this gene may be involved in the regeneration of the immune function (Singh et al., 2019); and this gene also was associated with body weight in Landrace pigs (Lee et al., 2018).
BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes
2016, Current BiologyCitation Excerpt :Impaired KIF13A function phenocopies the hypopigmentation of BLOC-1-deficient melanocytes [12], suggesting that both may function in the same process. Moreover, genetic variations in KIF13A or BLOC-1 subunits appear to predispose to neurological disorders like schizophrenia [18–20]. Here, we show that BLOC-1 coordinates the action of microtubule- and actin-dependent machineries to elongate, stabilize, and ultimately release RE tubules.
Quantitative analysis of intraneuronal transport in human iPS neurons
2015, Journal of Pharmacological SciencesCitation Excerpt :These findings illustrate the importance of intracellular transport in regulating higher functions of the nervous system. Disturbances in axonal transport and accumulations of organelles and proteins in axons, dendrites, and/or cell bodies contribute to the pathogenesis of many human neurodegenerative diseases (6–10). In addition, disruption of intraneuronal transport has been implicated in neuropathy induced by anti-neoplastic agents (11, 12).
De novo truncating mutation in kinesin 17 associated with schizophrenia
2010, Biological PsychiatryCitation Excerpt :First, abnormalities in expression of several genes implicated in presynaptic vesicular transport have been reported in SCZ (13,48). Second, kinesin member family 13A from the kinesin 1 superfamily has been proposed as a candidate gene for SCZ (49) and a positive association of KIF2 haplotypes was reported (50). Interestingly, one of the best candidate genes in SCZ, DISC1 (for review [51]), acts as a cargo receptor that links kinesin 1 heavy chain kinesin member family 5A to cargoes containing disrupted-in-schizophrenia 1-interacting proteins, including 14-3-3epsilon (YWHAE) (52) for which a positive association has been reported with SCZ (53).
Computational analysis of the effects of antineoplastic agents on axonal transport
2010, Journal of Pharmacological SciencesBipolar I disorder and schizophrenia: A 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios
2005, American Journal of Human Genetics
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Sequence data from this article have been deposited with the EMBL Data Library under Accession Nos. AJ291578 and AJ291579.
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To whom correspondence should be addressed at the Laboratoire d'Immunogénétique Humaine, INSERM E021, Institut Pasteur, 25, Rue du Docteur Roux, 75724 Paris Cedex 15, France. Telephone: (33) 1 40 61 32 16. Fax: (33) 1 40 61 31 53. E-mail: [email protected].