Regular ArticleQuantitative Trait Loci Affecting Prion Incubation Time in Mice
References (45)
- et al.
Characterization of two promoters for prion protein (PrP) gene expression in neuronal cells
Gene
(1997) - et al.
Linkage of prion protein and scrapie incubation time genes
Cell
(1986) - et al.
Identification of a gene which controls the incubation period of some strains of scrapie agent in mice
J. Comp. Pathol.
(1968) - et al.
MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations
Genomics
(1987) - et al.
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel
J. Mol. Biol.
(1999) Natural history and inherited disorders of a lysosomal enzyme, β-hexosaminidase
J. Biol. Chem.
(1989)- et al.
Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication
Cell
(1990) - et al.
A proximal mouse chromosome 9 linkage map that further defines linkage groups homologous with segments of human chromosomes 11, 15, and 19
Genomics
(1991) - et al.
Prion propagation in mice expressing human and chimeric transgene implicates the interaction of cellular PrP with another protein
Cell
(1995) - et al.
Characterization and analysis of branched-chain N-acetylglucosaminyl oligosaccharides accumulating in Sandhoff disease tissue. Evidence that biantennary bisected oligosaccharide side chains of glycoproteins are abundant substrates for lysosomes
J. Biol. Chem.
(1985)
Distinct prion proteins in short and long scrapie incubation period mice
Cell
Normal host prion protein necessary for scrapie-induced neurotoxicity
Nature
Genetic control of amyloid plaque production and incubation period in scrapie-infected mice
J. Neuropathol. Exp. Neurol.
High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene
Mol. Med.
Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice
Proc. Natl. Acad. Sci. USA
Genetics and polymorphism of the mouse prion gene complex: Control of scrapie incubation time
Mol. Cell. Biol.
Primary structure of prion protein may modify scrapie isolate properties
Proc. Natl. Acad. Sci. USA
Empirical threshold values for quantitative trait mapping
Genetics
Selective genotyping for determination of linkage between a marker locus and a quantitative trait locus
Theor. Appl. Genet.
Host–pathogen interactions in scrapie
Genetics
A genetic map of the mouse suitable for typing intraspecific crosses
Genetics
Permutation tests for multiple loci affecting a quantitative character
Genetics
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Prion Protein and Genetic Susceptibility to Diseases Caused by Its Misfolding
2017, Progress in Molecular Biology and Translational ScienceCitation Excerpt :Strains of mice that express identical PrP sequences can vary widely in prion incubation time, with the intervals from inoculation of RML prions to onset of disease ranging from 100 days in SJL/J to over 200 days.23,24,103 Quantitative trait analysis using microsatellite markers scattered across the genome of offspring of intercrosses and backcrosses between long and short incubation time Prnpa mouse strains identified several highly significant, but broad, chromosomal regions that harbored quantitative trait loci (QTL) affecting prion incubation time.104–107 The same chromosomal regions on Chr11 and Chr 2 were identified in independent studies, two of which used crosses involving the wild-derived CAST/Ei strain.
Omics of Prion Diseases
2017, Progress in Molecular Biology and Translational ScienceGenetics of prion diseases
2013, Current Opinion in Genetics and DevelopmentCitation Excerpt :Many regions are implicated although only loci on Mmu11 are replicated between the experimental models. Large regions of this chromosome have also been implicated in previous studies [21–23]. The main disadvantage of these studies is the limited resolution resulting in linkage to very large regions that have proved intractable for candidate gene identification.
Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins
2023, Prions and Diseases: Second EditionGenotype by environment interactions for chronic wasting disease in farmed US white-tailed deer
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