Regular ArticleThe Human Gene Encoding the Lectin-Type Oxidized LDL Receptor (OLR1) Is a Novel Member of the Natural Killer Gene Complex with a Unique Expression Profile☆
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Contribution of lectin-like oxidized low-density lipoprotein receptor-1 and LOX-1 modulating compounds to vascular diseases
2018, Vascular PharmacologyCitation Excerpt :Structurally, LOX-1 belongs to class E scavenger receptors, without sharing homology with other SRs. LOX-1 contains a domain common to C-type lectin receptors on natural killer cells and consists of four functional domains: a short N-terminal cytoplasmic, a connecting neck, a transmembrane and the lectin-like ligand binding domain, located at the extracellular C-terminus (Fig. 2) [11,16,37–40]. Uptake of oxLDL is mediated by six cysteine residues in the C-terminal lectin-like domain that are highly conserved among species [37].
LOX-1 receptor: A potential link in atherosclerosis and cancer
2018, Life SciencesCitation Excerpt :Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major ox-LDL receptor in endothelial cells [14], and it is also present in other cells such as smooth muscles cells and macrophages [15]. LOX-1 is a lectin-like 50-kD receptor that belongs to class E scavenger receptors [15,16] and contains a domain common to C-type lectin receptors on natural killer cells consisting of a short N terminal cytoplasmic domain, a connecting neck domain, a transmembrane and the lectin-like ligand binding domain, located at the extracellular C-terminus [17–20]. LOX-1 binds to its ligand through the formation of multimers and it is localized in lipid raft in the plasma membrane that lead to the internalization of the ligand [21–23].
Role of advanced glycation end products in cellular signaling
2014, Redox BiologyCitation Excerpt :This receptor was identified in endothelial cells as a receptor for OxLDL and has a molecular weight of 50 kDa [120]. LOX-1 is a type II transmembrane glycoprotein and belongs to the group V C-type lectins [121]. It is expressed with a short N-terminal cytoplasmic domain, a single transmembrane domain and a stalk region (NECK domain) with a subsequent C-terminal lectin-like domain (CTLD) in the extracellular region.
Lipids and lipoproteins may play a role in the neuropathology of Alzheimer’s disease
2023, Frontiers in NeurosciencePrognostic model of 10 immune-related genes and identification of small molecule drugs in bladder urothelial carcinoma (BLCA)
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Sequence data from this article have been deposited with the GenBank Data Library under Accession Nos. AF079164, AF079165, AF079166, and AF079167.
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To whom correspondence should be addressed at the Department of Pharmacology, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. Telephone: 81-6-645-3731. Fax: 81-6-646-1980. E-mail:[email protected].