Elsevier

Genomics

Volume 43, Issue 1, 1 July 1997, Pages 62-68
Genomics

Regular Article
Genetic and Physical Maps of the Stargazer Locus on Mouse Chromosome 15

https://doi.org/10.1006/geno.1997.4780Get rights and content

Abstract

The stargazer mouse mutation causes absence seizures that are more prolonged and frequent than any other petit mal mouse model. Stargazer mice also have an ataxic gait and vestibular problems, including a distinctive head-tossing motion. From the genotyping of a large intersubspecific cross, a panel of 53 recombinant DNAs betweenD15Mit29andD15Mit2has been assembled, and a fine genetic map of the stargazer region has been constructed on mouse Chromosome 15. The stargazer locus has been mapped betweenD15Mit30and the parvalbumin gene, and six candidate genes have been excluded by genetic linkage analysis. A physical contig of YACs, BACs, and P1s stretching 1.1 Mb fromD15Mit30to the somatostatin receptor 3 gene is reported, and the DNA interval including the stargazer locus has been narrowed to 150 kb.

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    V. E. AndersonW. A. HauserI. E. LeppikJ. L. NoebelsS. S. Rich, Eds.

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