Regular ArticleTwo-Locus Admixture Linkage Analysis of Bipolar and Unipolar Affective Disorder Supports the Presence of Susceptibility Loci on Chromosomes 11p15 and 21q22
References (0)
Cited by (84)
Two-Dimensional Genome Scan Identifies Multiple Genetic Interactions in Bipolar Affective Disorder
2010, Biological PsychiatryCitation Excerpt :Similarly, our data only partially support one interaction locus implicated through the conditional analysis of five specific linkage regions in the 153 US-based NIMH families at the 6q24–5q11 region (Pearson r = .369, unadjusted Pearson p = .0025) (62). An earlier two-locus study, which described an interaction between a bipolar linkage peak at 21q22 and genotypes within the tyrosine hydroxylase candidate gene on 11p15 (69), was also not supported in our data (Pearson r = −.016, unadjusted p = .898). It may be that, like many one-dimensional linkage scans for bipolar disorder, genetic heterogeneity has played a role in the failure of replication of interaction loci across these studies.
Bipolar Disorder in the Era of Genomic Psychiatry
2009, Genomic and Personalized Medicine, Two-Vol SetBipolar Disorder in the Era of Genomic Psychiatry
2008, Genomic and Personalized Medicine: V1-2Novel Linkage to Chromosome 20p Using Latent Classes of Psychotic Illness in 270 Irish High-Density Families
2008, Biological PsychiatryToward a biaxial model of "bipolar" affective disorders: Further exploration of genetic, molecular and cellular substrates
2006, Journal of Affective DisordersMolecular genetics of tyrosine 3-monooxygenase and inherited diseases
2005, Biochemical and Biophysical Research Communications
- 1
To whom correspondence should be addressed. Telephone: 0171 380 9474. Fax: 0171 436 5046. E-mail: [email protected].