Short CommunicationChromosome Mapping of the Human Arrestin (SAG), β-Arrestin 2 (ARRB2), and β-Adrenergic Receptor Kinase 2 (ADRBK2) Genes
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The association of β-arrestin2 polymorphisms with response to antidepressant treatment in depressed patients
2018, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Moreover, several monoaminergic receptors implied in MDD pathophysiology and targeted by current AD (as D1R, α1bAR and β2AR) are known to interact preferentially with β-arrestin 2 (Oakley et al., 2000). ARRB2 gene is located within the 17p13 region on chromosome 17 (Calabrese et al., 1994). In the past decade, several studies showed the association between β-arrestin 2 single nucleotide polymorphisms (SNPs) and mental disorders, like substance abuse disorders ((Sun et al., 2008), (Bousman et al., 2010; Ikeda et al., 2007)).
Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins
2014, NeuropharmacologyCitation Excerpt :All other drugs were purchased from Sigma–Aldrich (Milan, Italy). The plasmids encoding for GRK2, GRK4, GRK6, β-arrestin1 (βarr1), β-arrestin2 (βarr2) and βarrV53D, the dominant negative of βarr1 (βarrDN) cDNAs were previously described (Calabrese et al., 1994; Iacovelli et al., 2003). The plasmids encoding for the kinase-dead mutant of GRK2 (GRK2-K220R) and the C-terminal domain of GRK2 (Gly495-Leu689) (GRK2-Cter) were kindly provided by C. Scorer (GlaxoSmithKline, Uxbridge, Middlesex, UK); DynK44A cDNA was kindly provided by J. Benovic; Ha-tagged mGlu7 receptor and human EAAC1 cDNA were kindly provided by J. P. Pin (CNRS, Montpellier, France).
A genome-wide scan of serum lipid levels in the Old Order Amish
2004, Atherosclerosisp53 Loss and point mutations are associated with suppression of apoptosis and progression of CML into myeloid blastic crisis
1997, Cancer Genetics and Cytogenetics