Elsevier

Genomics

Volume 22, Issue 3, August 1994, Pages 563-568
Genomics

Regular Article
Isolation of a Yeast Artificial Chromosome Contig Spanning the Greig Cephalopolysyndactyly Syndrome (GCPS) Gene Region

https://doi.org/10.1006/geno.1994.1429Get rights and content

Abstract

Disruption of the zinc finger gene GLI3 has been shown to be the cause of Greig cephalopolysyndactyly syndrome (GCPS), at least in some GCPS translocation patients. To characterize this genomic region on human chromosome 7p13, we have isolated a YAC contig of more than 1000 kb including the GLI3 gene. In this contig the gene itself spans at least 200-250 kb. A CpG island is located in the vicinity of the 5′ region of the known GLI3 cDNA, implying a potential promoter region.

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