Elsevier

Genomics

Volume 19, Issue 1, 1 January 1994, Pages 42-47
Genomics

Regular Article
A 6.5-Mb Yeast Artificial Chromosome Contig Incorporating 33 DNA Markers on the Human X Chromosome at Xq22

https://doi.org/10.1006/geno.1994.1010Get rights and content

Abstract

The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome.

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