Elsevier

Cytokine

Volume 19, Issue 3, August 2002, Pages 138-146
Cytokine

Regular Articles
GENETIC AND ENVIRONMENTAL INFLUENCES ON IL-6 AND TNF-α PLASMA LEVELS IN APPARENTLY HEALTHY GENERAL POPULATION

https://doi.org/10.1006/cyto.2002.1959Get rights and content

Abstract

Dysregulation of cytokines synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, and others, but observational studies have led to contradictory results. We investigated potential familial influences on the plasma levels of IL-6 and TNF-α in 91 nuclear and more complex pedigrees of Caucasian ethnic origin (N=401 individuals). The maximum likelihood based variance decomposition analysis showed significant positive correlation between circulating IL-6 and age in both genders. The magnitude of these correlations in our sample ranged from 0.22 in females to 0.28 in males (P <0.001). Significant association between TNF-α and IL-6 (r=0.28, r=0.43; P <0.001; respectively for men and women) was also observed. Likelihood ratio test clearly revealed that additive genetic effect for TNF-α was highly significant (P <0.001), and accounted over 80% of its variation, adjusted for IL-6 levels and age. In contrast, heritability estimate for IL-6 adjusted for age and TNF-α, revealed small contribution of genetic factors (24.1±10.2%). The bivariate variance component analysis demonstrated that significant relationship between IL-6 and TNF-α was due to shared environment only (rE=0.760±0.140). As evinced from our complex segregation analysis the nature of the genetic determinant of each of these two cytokines is quite complex and it is probably oligogenic.

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    Correspondence to: Prof. Gregory Livshits, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel. Fax: +972-3-640-8287; E-mail: [email protected]

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