Regular ArticlesGENETIC AND ENVIRONMENTAL INFLUENCES ON IL-6 AND TNF-α PLASMA LEVELS IN APPARENTLY HEALTHY GENERAL POPULATION
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Cited by (54)
Family-based analyses reveal novel genetic overlap between cytokine interleukin-8 and risk for suicide attempt
2019, Brain, Behavior, and ImmunityCitation Excerpt :The heritability of TNF-α, IL-6 and IL-8 have been published previously. Heritability estimates of IL-6 from twin studies range between 0.17 and 0.61, though the majority of studies indicate estimates closer to 0.61 (de Craen et al., 2005; Amaral et al., 2015; Worns et al., 2006; Pantsulaia et al., 2002; de Maat et al., 2004; Posthuma et al., 2005). The classical twin design has been criticized for giving upwardly biased heritability estimates (Joseph, 2002; Kendler et al., 2016; Benchek and Morris, 2013).
Contribution of putative genetic factors and candidate gene variants to inter-individual variation of circulating fractalkine (CX3CL1) levels in a large UK twins' sample
2013, Human ImmunologyCitation Excerpt :These estimates are in good agreement with previously published data on a variety of cytokines, including several chemokines. The heritability estimates in these studies vary in wide range, from 10% to 80% depending on the cytokine and the sample [11–15]. For example, Pantsulaia et al. [13] reported that adjusted for potential covariates, 72% of the MCP-1 variance, was attributable to familial effects.
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Correspondence to: Prof. Gregory Livshits, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel. Fax: +972-3-640-8287; E-mail: [email protected]