Biochemical and Biophysical Research Communications
Regular ArticleGenetic Alterations ofp16INK4aandp53Genes in Sporadic Dysplastic Nevus☆,☆☆,★
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2013, Journal of the American Academy of DermatologyCitation Excerpt :Genetic studies also have been used to support the concept of stepwise progression from nevus to melanoma. Dysplastic nevi, like melanomas, commonly harbor mutations in BRAF, NRAS, mismatch repair proteins, and other genes.8,42-46 However, studies to date have evaluated spatially separate nevi and melanomas, and it is not clear that documented mutations in BRAF and NRAS oncogenes lead to the same effects in nevi as they do in melanomas.47,48
Dysplastic Nevi
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This work was supported by the Catholic Medical Center Research Fund for special projects.
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Abbreviations: SDN, sporadic form of dysplastic nevusLOH, loss of heterozygosity; CMM, cutaneous malignant melanoma;
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A. B. Ackerman, Ed.
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