Univariable and multivariable logistic regression model for functional MMR tumour testing in patients with endometrial cancer
| Functional MMR test | Univariable | Multivariable n=5200 | |||||
| Not tested | Tested | OR (95% CI) | P value | OR (95% CI) | P value | P trend | |
| Age group (years) | |||||||
| 70+ | 3037 (86.4) | 477 (13.6) | – | – | <0.0001 | ||
| 50–69 | 3151 (80.9) | 743 (19.1) | 1.50 (1.32 to 1.70) | <0.0001 | 1.48 (1.24 to 1.77) | <0.0001 | |
| 30–49 | 323 (64.3) | 179 (35.7) | 3.53 (2.87 to 4.33) | <0.0001 | 6.60 (4.87 to 8.95) | <0.0001 | |
| 0–29 | 9 (50.0) | 9 (50.0) | 6.37 (2.47 to 16.4) | 0.0001 | 14.5 (3.65 to 59.3) | 0.0001 | |
| IMD quintile | |||||||
| Q1—most deprived | 1209 (85.4) | 207 (14.6) | – | – | 0.083 | ||
| Q2 | 1233 (79.4) | 319 (20.6) | 1.51 (1.25 to 1.83) | <0.0001 | 1.29 (0.97 to 1.71) | 0.077 | |
| Q3 | 1385 (82.7) | 290 (17.3) | 1.22 (1.01 to 1.49) | 0.042 | 1.18 (0.89 to 1.56) | 0.25 | |
| Q4 | 1363 (81.3) | 313 (18.7) | 1.34 (1.11 to 1.63) | 0.0027 | 1.52 (1.15 to 2.00) | 0.0029 | |
| Q5—least deprived | 1330 (82.7) | 279 (17.3) | 1.23 (1.01 to 1.49) | 0.042 | 1.21 (0.91 to 1.62) | 0.18 | |
| Ethnicity | |||||||
| White | 5444 (83.2) | 1101 (16.8) | – | – | |||
| Asian | 252 (73.7) | 90 (26.3) | 1.77 (1.37 to 2.26) | <0.0001 | 0.55 (0.38 to 0.79) | 0.0017 | |
| Black | 140 (70.7) | 58 (29.3) | 2.05 (1.49 to 2.79) | <0.0001 | 0.84 (0.48 to 1.46) | 0.55 | |
| Chinese | 15 (60.0) | 10 (40.0) | 3.30 (1.43 to 7.28) | 0.0036 | 1.72 (0.59 to 4.81) | 0.31 | |
| Mixed | 28 (65.1) | 15 (34.9) | 2.65 (1.38 to 4.90) | 0.0025 | 3.03 (1.23 to 7.45) | 0.015 | |
| Other | 93 (75.0) | 31 (25.0) | 1.65 (1.08 to 2.46) | 0.017 | 0.59 (0.32 to 1.05) | 0.080 | |
| Stage at diagnosis | |||||||
| 1 | 4189 (83.4) | 836 (16.6) | – | – | 0.22 | ||
| 2 | 353 (77.4) | 103 (22.6) | 1.46 (1.15 to 1.84) | 0.0013 | 1.41 (1.03 to 1.91) | 0.027 | |
| 3 | 444 (75.5) | 144 (24.5) | 1.63 (1.32 to 1.98) | <0.0001 | 1.75 (1.32 to 2.30) | 0.0001 | |
| 4 | 408 (82.3) | 88 (17.7) | 1.08 (0.84 to 1.37) | 0.53 | 1.20 (0.82 to 1.73) | 0.34 | |
| Grade of tumour | |||||||
| G1—well differentiated | 2938 (84.0) | 559 (16.0) | – | – | 0.045 | ||
| G2—moderately differentiated | 1364 (79.3) | 357 (20.7) | 1.38 (1.19 to 1.59) | <0.0001 | 1.51 (1.24 to 1.83) | <0.0001 | |
| G3—poorly differentiated | 1041 (77.8) | 297 (22.2) | 1.50 (1.28 to 1.75) | <0.0001 | 1.95 (1.57 to 2.43) | <0.0001 | |
| G4—undifferentiated/anaplastic | 33 (66.0) | 17 (34.0) | 2.71 (1.46 to 4.83) | 0.00098 | 2.34 (0.91 to 5.71) | 0.067 | |
| Cancer Alliance (pseudonym) | |||||||
| MM | 213 (98.6) | 3 (1.4) | – | – | |||
| PP | 248 (97.3) | 7 (2.7) | 2.00 (0.55 to 9.39) | 0.32 | 1.73 (0.37 to 9.02) | 0.48 | |
| OO | 358 (96.0) | 15 (4.0) | 2.97 (0.97 to 13.0) | 0.088 | 2.42 (0.72 to 11.0) | 0.19 | |
| … | … | … | … | … | … | … | |
| II | 317 (64.0) | 178 (36.0) | 39.9 (14.9 to 163) | <0.0001 | 34.9 (12.6 to 145) | <0.0001 | |
| RR | 154 (38.8) | 243 (61.2) | 112 (41.7 to 458) | <0.0001 | 210 (73.7 to 886) | <0.0001 | |
Unadjusted ORs are presented from univariable regression models including each single variable in turn. Missing data variables are excluded. Adjusted ORs are presented from a multivariable regression model including all variables in the table. Patients with missing data in any of the variables are excluded (n=2728), resulting in inclusion of 5200 patients in the multivariable model. Abbreviated results (highest and lowest ORs) are presented for the Cancer Alliance (full results available in online supplemental table 4). P values <0.05 are highlighted in bold. ORs and p values are presented to three and two significant figures, respectively.
IMD, index of multiple deprivation; MMR, mismatch repair.