Table 1

PV detection rates by Manchester Scoring System and age of sporadic male breast cancer

MSSNumber testedBRCA1 PVs
(%)
BRCA2 PVs
(%)
BRCA1/2 (%)CHEK2%Other genes testedPositive
<15631 (1.59%)5 (7.94%)9.52%34.76%430
15–19511 (1.96%)9 (17.65%)19.61%00.00%200
20–29500 (0%)12 (24.0%)24.00%12.00%170
30–39262 (7.69%)14 (53.85%)61.54%13.85%90
≥40141 (7.14%)11 (78.57%)85.71%00.00%40
Total2045 (2.45%)51 (25.0%)27.45%52.45%930
>29 no BRCA1/212N/aN/a18.33%110
Sporadic MBC
<60221 (4.55%)0 (0%)4.55%29.09%150
≥60250 (0%)2 (8.0%)8.00%14.00%230
Total471 (2.13%)2 (4.26%)6.38%36.38%380
  • PV, pathogenic variant.