Adjusted p value, p value after applying genomic control correction (inflation factor λ=1.11) to the New.STP_p χ² test statistic; L, number of variant sites that are considered ‘rare’ (alternate allele read count frequency AACF <0.05); M_p, estimated number of SNVs in the dataset; M_s, number of variant sites screened in; M_st, number of variant sites screened in and passing threshold AACF >1/(2n), where n=128+248 (the cohort size); New.SB_p, p value of the ‘New-SB’ test (based on M_s); New.STP_p, p value of the ‘New-STB’ test (based on M_st).