Table 1

Published studies and meta-analysis of constitutional APC I1307K in AJ CRC patients and AJ controls

StudyAJ individuals
CRC cases
I1307K/total (%)
Controls
I1307K/total (%)
OR (95% CI), p value*
Laken et al (1997)3 22/211 (10.43)47/766 (6.14)1.78 (0.99 to 3.10), p=0.047
Woodage et al (1998)30 7/55 (12.7)355/4948 (7.2)1.88 (0.71 to 4.23), p=0.12
Rozen et al (1999)7 3/51 (5.9)†6/120 (5.0)1.19 (3.18 to 5.83), p=1
Drucker et al (2000)27 12/71 (16.9)17/298 (5.7)2.15 (0.88 to 5.12), p=0.07
Shtoyerman-Chen et al (2001)31 29/227 (12.77)8/148 (5.41)2.56 (1.1 to 6.77), p=0.02
Stern et al (2001)28 6/22 (27.27)17/209 (8.13)4.19 (1.19 to 13.30), p=0.01
Figer et al (2001)59 8/50 (16.0)8/148 (5.4)3.31 (1.02 to 10.80), p=0.03
Rozen et al (2002)26 6/77 (7.8)12/194 (6.2)1.28 (0.38 to 3.86), p=0.6
Strul et al (2003)38 26/267 (9.7)17/204 (8.33)1.19 (0.60 to 2.40), p=0.6
Fidder et al (2005)60 35/322 (10.9)13/260 (5)2.31 (1.16 to 4.88), p=0.015
Boursi et al (2013)6 37/299 (12.3)86/1089 (7.9)1.65 (1.06 to 2.51), p=0.02
Forkosh et al (2022)10 145/1306 (11.1)342/4918 (6.9)‡1.67 (1.35 to 2.06), p=1.8 x 10-6
Gryfe et al (1999)37 41/404 (10.1)
Figer et al (2001)32 23/189 (12.17)
Zauber et al (2003)61 22/182 (12.1)§
Rennert et al (2005)42 71/633 (9.6)
Zauber et al (2005)34 12/74 (16.2)
Locker et al (2006)29 26/215 (12.1)
Ukaegbu et al (2021)35 35/285 (13)
Total 566/4940 (11.5) 928/12945 (7.2) 1.68 (1.50 to 1.87), p<2.2 x 10−16
1.78 (1.54 to 2.06), p<0.00001¶
  • *Fisher’s exact test. Calculations made for this publication. Results may not coincide with the original publications due to the application of different adjustments to the tests in their analyses.

  • †Individuals with personal or family history of colorectal neoplasia (CRC or adenoma).

  • ‡Control data obtained from gnomAD.

  • §172 patients with colorectal neoplasia (CRC or adenoma) and 10 first-degree relatives without neoplasia.

  • ¶Logistic regression.

  • AJ, Ashkenazi Jewish; CRC, colorectal cancer.