Table 2

The rates are the percentage of mutation carriers in the Colombian and global population, using the 1000 Genomes Project

Cases	Gene	Position at cDNA	Protein change	rs	Variant type	GMAF	Colombian rate
Case 1	TREM2	c.469C>T	p.H157Y	rs2234255	Missense	0.0028	0.020
	TREM2	c.185G>A	p.R62H	rs143332484	Missense	0.0049	0.016
	VAPB	c.510G>A	p.M170I	rs143144050	Missense	0.0010	0.000
	DCTN1	c.1998G>A	p.T666=	rs149900553	Synonymous	0.0008	1000
	SETX	c.6507G>A	p.G2169=	rs34073320	Synonymous	0.0098	0.037
	LRRK2	c.4624C>T	p.P1542S	rs33958906	Missense	0.0132	0.069
Case 2	TREM2	c.469C>T	p.H157Y	rs2234255	Missense	0.0028	0.020
	OPTN	c.1339ª>G	p.M447V		Missense	ND	ND
	SNCA	c.216G>A	p.Thr72=	rs144758871	Synonymous	ND	ND
Case 3	TREM2	c.469C>T	p.H157Y	rs2234255	Missense	0.0028	0.020
Case 3	MFSD8	c.1153G>C	p.G385R	rs11098943	Missense	ND	ND

DCTN1, dynactin subunit 1; GMAF, global minor allele frequency; LRRK2, leucine-rich repeat kinase 2; MSFD8, major facilitator superfamily domain-containing protein 8; ND, no data; OPTN, optineurin; SETX, senataxin; SNCA, synuclein alpha; TREM2, triggering receptor expressed on myeloid cells 2; VAPB, VAMP-associated protein B and C.