Published studies and meta-analysis of constitutional APC I1307K in non-AJ Jewish CRC patients and controls
| Study | Non-AJ Jewish individuals | ||
| CRC cases I1307K/total (%) | Controls I1307K/total (%) | OR (95% CI), p value* | |
| Rozen et al (1999)7 | 0/17 (0.0)† | 1/188 (0.5) | 0.00 (0.00 to 428.41), p=1 |
| Drucker et al (2000)27 | 3/38 (7.9)‡ | 9/189 (4.8)‡ | 1.62 (0.27 to 6.90), p=0.4 |
| Shtoyerman-Chen et al (2001)31 | 2/122 (1.6) | 4/370 (1.1) | 1.52 (0.14 to 10.78), p=0.6 |
| Rozen et al (2002)26 | 0/20 (0.0)§ | 3/199 (1.51) | 0.00 (0.00 to 24.80), p=1 |
| Fidder et al (2005)33 | 4/165 (2.42) | 3/151 (1.99) | 1.22 (0.20 to 8.50), p=1 |
| Figer et al (2001)32 | 2/80 (2.5)¶ | – | – |
| Figer et al (2001)59 | 0/25 (0.0)¶ | – | – |
| Rennert et al (2005)42 | 5/184 (2.7) | – | – |
| Total | 16/651 (2.5) | 20/1097 (1.8) | 1.36 (0.65 to 2.78), p=0.39 1.35 (0.57 to 3.19), p=0.49** |
*Fisher’s exact test. Calculations made for this publication. Results may not coincide with the original publications due to the application of different adjustments to the tests in their analyses.
†Individuals with personal or family history of colorectal neoplasia (CRC or adenoma).
‡All I1307K heterozygotes are Yemenite Jews.
§Individuals with colorectal neoplasia (CRC or adenoma).
¶Some Israeli Arabs included.
**Logistic regression.
AJ, Ashkenazi Jewish; CRC, colorectal cancer.