Published studies and meta-analysis of constitutional APC I1307K in AJ CRC patients and AJ controls
| Study | AJ individuals | ||
| CRC cases I1307K/total (%) | Controls I1307K/total (%) | OR (95% CI), p value* | |
| Laken et al (1997)3 | 22/211 (10.43) | 47/766 (6.14) | 1.78 (0.99 to 3.10), p=0.047 |
| Woodage et al (1998)30 | 7/55 (12.7) | 355/4948 (7.2) | 1.88 (0.71 to 4.23), p=0.12 |
| Rozen et al (1999)7 | 3/51 (5.9)† | 6/120 (5.0) | 1.19 (3.18 to 5.83), p=1 |
| Drucker et al (2000)27 | 12/71 (16.9) | 17/298 (5.7) | 2.15 (0.88 to 5.12), p=0.07 |
| Shtoyerman-Chen et al (2001)31 | 29/227 (12.77) | 8/148 (5.41) | 2.56 (1.1 to 6.77), p=0.02 |
| Stern et al (2001)28 | 6/22 (27.27) | 17/209 (8.13) | 4.19 (1.19 to 13.30), p=0.01 |
| Figer et al (2001)59 | 8/50 (16.0) | 8/148 (5.4) | 3.31 (1.02 to 10.80), p=0.03 |
| Rozen et al (2002)26 | 6/77 (7.8) | 12/194 (6.2) | 1.28 (0.38 to 3.86), p=0.6 |
| Strul et al (2003)38 | 26/267 (9.7) | 17/204 (8.33) | 1.19 (0.60 to 2.40), p=0.6 |
| Fidder et al (2005)60 | 35/322 (10.9) | 13/260 (5) | 2.31 (1.16 to 4.88), p=0.015 |
| Boursi et al (2013)6 | 37/299 (12.3) | 86/1089 (7.9) | 1.65 (1.06 to 2.51), p=0.02 |
| Forkosh et al (2022)10 | 145/1306 (11.1) | 342/4918 (6.9)‡ | 1.67 (1.35 to 2.06), p=1.8 x 10-6 |
| Gryfe et al (1999)37 | 41/404 (10.1) | – | – |
| Figer et al (2001)32 | 23/189 (12.17) | – | – |
| Zauber et al (2003)61 | 22/182 (12.1)§ | – | – |
| Rennert et al (2005)42 | 71/633 (9.6) | – | – |
| Zauber et al (2005)34 | 12/74 (16.2) | – | – |
| Locker et al (2006)29 | 26/215 (12.1) | – | – |
| Ukaegbu et al (2021)35 | 35/285 (13) | – | – |
| Total | 566/4940 (11.5) | 928/12945 (7.2) | 1.68 (1.50 to 1.87), p<2.2 x 10−16 1.78 (1.54 to 2.06), p<0.00001¶ |
*Fisher’s exact test. Calculations made for this publication. Results may not coincide with the original publications due to the application of different adjustments to the tests in their analyses.
†Individuals with personal or family history of colorectal neoplasia (CRC or adenoma).
‡Control data obtained from gnomAD.
§172 patients with colorectal neoplasia (CRC or adenoma) and 10 first-degree relatives without neoplasia.
¶Logistic regression.
AJ, Ashkenazi Jewish; CRC, colorectal cancer.