Baseline characteristics of participants with Fabry disease-causing variants
| Combined | Male (M) | Female (F) | Background* | Significance | |
| n (%) | 36 (100) | 15 (42) | 21 (58) | 44.9 M, 55.1 F | p=0.69† |
| Age (years), mean (SD) | 54.8±8.4 | 53.1±8.7 | 55.3±8.4 | 56.7±8.2M, 56.3±8.0 F | p=0.13 M, p=0.60 F‡ |
| Diagnosed Fabry disease | 3 | 2 | 1 | 0 | NT |
| Cardiovascular disease, n (%) | 10 (27.8) | 6 (40) | 4 (19) | 18 221 (20) M, 11 557 (10) F | p=0.099 M, p=0.27 F |
| Hearing impairment, n (%) | 1 (2.8) | 1 | 0 | 3773 (1.88) | NT |
| CKD-EPI eGFR mL/min/1.73 m2§ | 90±15 | 93±14 | 89±15 | 92±14 M, 91±13 F | p=0.91 M, p=0.50 F‡ |
| Microalbuminuria (n=35)¶, n (%) | 7 (20) | 5 (35.7) | 2 (9.5) | 4935 (5.6) M, 5185 (4.9) F | p=0.0007 M, p=0.27 F |
P values are for combined men and women with Fabry-causing variants versus the background cohort unless specified otherwise using Fisher’s exact test.
*n=200 596 (194 578 for ACR data).
†Pearson’s χ2.
‡Independent samples t-test.
§Creatinine missing for one woman.
¶ACR missing for one man.
**
ACR, albumin–creatinine ratio; CKD-EPI eGFR, Chronic Kidney Disease Epidemiology Collaboration estimated glomerular filtration rate; NT, not tested.