Results of the association analyses between breast cancer and the PRS313
| Cases (n) | OR | 95% CI | P value | |
| Main analysis | ||||
| Overall breast cancer | 1968 | 1.97 | 1.84 to 2.11 | <2.00×10−16 |
| Secondary analyses* | ||||
| Invasive breast cancer | 1701 | 2.00 | 1.86 to 2.15 | <2.00×10−16 |
| In situ breast cancer | 262 | 1.69 | 1.50 to 1.89 | <2.00×10−16 |
| Categorical PRS313† | ||||
| 0–10 | 21 | 0.10 | 0.06 to 0.17 | <2.00×10−16 |
| 10–20 | 58 | 0.30 | 0.21 to 0.42 | 2.30×10−11 |
| 20–40 | 222 | 0.66 | 0.52 to 0.82 | 2.20×10−04 |
| 40–60 (reference) | 354 | 1.00 | NA | NA |
| 60–80 | 491 | 1.37 | 1.13 to 1.66 | 1.10×10−3 |
| 80–90 | 396 | 2.27 | 1.84 to 2.79 | 1.10×10−14 |
| 90–100 | 426 | 2.29 | 1.86 to 2.83 | 8.90×10−15 |
*Individuals with unknown invasiveness (n=3) and individuals with unknown age of diagnosis of the (second) invasive breast tumour (n=2) were excluded.
†Category boundaries of the PRS313 were −3.93, −1.27, −0.88, −0.26, 0.23, 0.84, 1.34 and 3.41.
PRS, Polygenic Risk Score.