Breakdown of VYOC cases by histological subtype
Histological subtype | n (%) | Carriers of PV detected (%) | PV details |
HGSOC | 6 (7.8) | 0 | NA |
LGSOC | 4 (5.2) | 0 | NA |
Poorly differentiated | 1 (1.3) | 0 | NA |
Serous NOS | 12 (15.6) | 1 (8.3) | MSH2x1 |
Endometrioid | 7 (9.1) | 2 (28.6) | MSH2x1, PMS2x1 |
Clear cell | 2 (2.6) | 1 (50) | MSH2x1 |
Mucinous | 29 (37.7) | 0 | NA |
Borderline | 9 (11.7) | 0 | NA |
Granulosa cell | 1 (1.3) | 0 | NA |
Adenocarcinoma NOS | 1 (1.3) | 0 | NA |
Unknown | 5 (6.5) | 1 (20) | MSH2x1 |
Total | 77 | 5 (6.5%) | MSH2x4, PMS2x1 |
HGSOC, high-grade serous ovarian cancer; LGSOC, low-grade serous ovarian cancer; NA, Not Applicable; NOS, not otherwise specified; PV, pathogenic variant; VYOC, very young onset ovarian cancer.