Demographic and neuropsychological data comparison between TREM2 cases, Ng-FTD controls and HC
| TREM2 | TREM2 | TREM2 | Ng-FTD | HC | Ng-FTD-MND | |
| Case 1 | Case 2 | Case 3 | Controls (n=5) | (n=5) | Controls (n=11) | |
| Demographic data | ||||||
| Age (years), SD | 63 | 61 | 56 | 62.8, SD (6.1) | 61.3, SD (3.9) | 61.16, SD (11.6) |
| Education (years), SD | 9 | 8 | 14 | 10.6, SD (3.7) | 11.3, SD (2.9) | 15.5, SD (2.0) |
| Neuropsychological data | ||||||
| General cognitive assessment | ||||||
| MoCA | 12 | 9 | 20 | 15.9, SD (1.9) | 26.5, SD(2.1) | 21.5, SD(12.5) |
| Executive function | ||||||
| Total IFS score | 9 | 5 | 16.3, SD (2.6) | 22.1, SD (1.9) | 22.1, SD (1.9) | |
| Hayling test | 16 | 18 | 23.5, SD (9.6) | 10.6, SD (2.6) | 10.6, SD (2.6) | |
| Stroop test | 55 | 38.7, SD (34.9) | ||||
| Social cognition | ||||||
| RMET | 8 | 6 | 13.3, SD (2.1) | 14.3, SD (1.1) | 14.3, SD (1.1) | |
| Social changes in NPI | 5 | 2.7, SD (3.7) | ||||
| Behavioural changes | ||||||
| FrSBe Total | 134 | 188 | 115, SD (33.5) | 9.5, SD (1.1) | 9.5, SD (1.1) | |
| FrSBe Apathy | 22 | 18 | 38.5, SD (10.8) | 3.1, SD (.6) | 3.1, SD (.6) | |
| FrSBe Disinhibition | 55 | 58 | 28.6, SD (11.7) | 3.1, SD (.6) | 3.1, SD (.6) | |
| FrSBe Executive functions | 49 | 77 | 47.6, SD(12.4) | 3.3, SD(.4) | 3.3, SD(.4) | |
| NPI Total scores | 73 | 21.9, SD (21.7) |
Data shown as mean with SD reported.
FrSBe, Frontal Systems Behavioural Scale; HC, healthy control; IFS, Ineco Frontal Screening; MoCA, Montreal Cognitive Assessment; NPI, Neuropsychiatric Inventory; RMET, Reading Mind in the Eyes Test.