Risk of epithelial ovarian cancer in family members of cases versus family members of controls in the Utah Population Database, stratified by year of diagnosis
| FRR of ovarian cancer among FDRs of cases vs controls | FRR of ovarian cancer among SDRs of cases vs controls | FRR of ovarian cancer among TDRs of cases vs controls | |||||||
| Case FDRs (cases/total) | Control FDRs (cases/total) | FRR (95% CI) | Case SDRs (cases/total) | Control SDRs (cases/total) | FRR (95% CI) | Case TDRs (cases/total) | Control TDRs (cases/total) | FRR (95% CI) | |
| 1966–1994 | |||||||||
| Model 1* | 67/11 124 | 409/116 350 | 1.65 (1.28 to 2.14) | 123/29 929 | 785/312 899 | 1.55 (1.28 to 1.87) | 310/72 196 | 2073/727 043 | 1.49 (1.31 to 1.70) |
| 1995–2004 | |||||||||
| Model 1* | 20/4866 | 92/48 530 | 2.09 (1.29 to 3.38) | 14/12 204 | 113/123 894 | 1.22 (0.70 to 2.12) | 43/27 057 | 391/269 192 | 1.06 (0.73 to 1.55) |
| Model 2† | 20/4866 | 92/48 530 | 2.10 (1.30 to 3.40) | 14/12 204 | 113/123 894 | 1.22 (0.70 to 2.12) | 43/27 057 | 391/269 192 | 1.06 (0.73 to 1.55) |
| 2005–2016 | |||||||||
| Model 1* | ‡/2369 | 34/22 858 | 1.01 (0.36 to 2.87) | ‡/6145 | 62/62 724 | 1.25 (0.60 to 2.61) | 22/13 421 | 159/133 845 | 1.37 (0.88 to 2.12) |
| Model 2† | ‡/2369 | 34/22 858 | 1.02 (0.36 to 2.90) | ‡/6145 | 62/62 724 | 1.26 (0.61 to 2.63) | 22/13 421 | 159/133 845 | 1.37 (0.88 to 2.13) |
*Model 1: competing risk Cox proportional hazards models with censoring at death or loss to follow-up, and adjustment for birth year, born in Utah, race and ethnicity.
†Model 2: competing risk Cox proportional hazards models with censoring at death, bilateral oophorectomy or loss to follow-up, and adjustment for birth year, born in Utah, race, ethnicity, ever parous, number of live births, births outside of Utah, ever unilateral oophorectomy, ever unilateral salpingectomy, ever bilateral salpingectomy, ever tubal ligation and ever pelvic surgery not otherwise specified.
‡Consistent with the Utah Department of Health confidentiality policies, we have masked low counts (n<11) and any counts that could be used to re-create the low counts.
FDR, first-degree relative; FRR, familial relative risk; SDR, second-degree relative; TDR, third-degree relative.