Risk of epithelial ovarian cancer in FDRs of ovarian cancer probands versus FDRs of controls in the Utah Population Database (1966–2016)
| FRR of ovarian cancer among women with affected mothers (FDR-M) vs women with unaffected mothers (FDR-CM) | FRR of ovarian cancer among women with affected sisters (FDR-S) vs women with unaffected sisters (FDR-CS) | FRR of ovarian cancer among women with affected daughters (FDR-D) vs women with unaffected daughters (FDR-CD) | |||||||
| FDR-M (n=4131) | FDR-CM (n=33 695) | FRR* (95% CI) | FDR-S (n=4053) | FDR-CS (n=32 164) | FRR* (95% CI) | FDR-D (n=1809) | FDR-CD (n=13 070) | FRR* (95% CI) | |
| All EOC | 33 | 144 | 1.91 (1.30 to 2.79) | 50 | 253 | 1.63 (1.07 to 2.46) | 30 | 104 | 2.19 (1.45 to 3.32) |
| HGSC | 14 | 76 | 1.60 (0.90 to 2.85) | 23 | 134 | 1.47 (0.86 to 2.52) | 16 | 60 | 2.07 (1.17 to 3.65) |
| EC | † | 14 | 1.30 (0.27 to 6.21) | † | 25 | 1.76 (0.65 to 4.73) | † | 21 | 2.37 (0.94 to 6.01) |
| CCC | † | † | 2.16 (0.23 to 19.95) | † | † | 0.75 (0.08 to 6.72) | † | † | 1.39 (0.26 to 7.53) |
| MC | † | 11 | 3.89 (1.41 to 10.71) | † | 28 | 0.87 (0.26 to 2.90) | † | 11 | 2.03 (0.54 to 7.65) |
| LGSC | † | † | ‡ | † | † | ‡ | † | † | ‡ |
| Other epithelial | 12 | 51 | 1.93 (1.02 to 3.63) | 21 | 85 | 2.25 (1.30 to 3.90) | † | 18 | 3.66 (1.48 to 9.02) |
Other epithelial: an amalgamation of carcinoma not otherwise specified, mixed tumours, carcinosarcoma and malignant Brenner.
*Results were generated using competing risk Cox proportional hazards models with censoring at death, bilateral oophorectomy or loss to follow-up, and adjustment for birth year, born in Utah, race, ethnicity, ever parous, number of live births, births outside of Utah, ever unilateral oophorectomy, ever unilateral salpingectomy, ever bilateral salpingectomy, ever tubal ligation and ever pelvic surgery.
†Consistent with the Utah Department of Health confidentiality policies, we have masked low counts (n<11) and any counts that could be used to re-create the low counts.
‡Model does not converge.
CCC, clear cell carcinoma; EC, endometrioid carcinoma; EOC, epithelial ovarian cancer; FDR, first-degree relative; FRR, familial relative risk; HGSC, high-grade serous carcinoma; LGSC, low-grade serous carcinoma; MC, mucinous carcinoma.