Table 2

Patients with secondary tumours after diagnosis of MB

StudyStatus and age range at last follow-upAge range at MB onset (histological type if available)RTSecondary malignanciesOther tumour(s)Number of BCC
Smith et al 8
Evans et al 19
Alive (30 s)Infant
(desmoplastic)
YesBCCMeningioma
Pilocytic astrocytoma
65
Smith et al 8
Evans et al 19
Alive (30 s)Infant
(desmoplastic)
YesBCCMeningioma3
Smith et al 8
Evans et al 19
Alive (20 s)Infant
(desmoplastic)
YesBCCUnilateral ovarian fibroma11
Taylor et al 14
Ng et al 23
Alive
(20 s)
NA
(desmoplastic)
YesMeningiomaNone
Kijima et al 26 Alive (30 s)InfantNABCCMeningiomaNA
Mann et al 28 Dead (childhood)Infant
(desmoplastic)
NABCC infundibulocysticNA
Mann et al 28 Dead (infant)InfantNASkin hamartomaNone
Guerrini-Rousseau et al 31 Alive (10 s)Infant
(MBEN)
NoStromal ovarian tumourMeningiomaNone
Guerrini-Rousseau et al 31 Dead (childhood)Infant
(MBEN)
Yes (PF only)AMLNone
Guerrini-Rousseau et al 31 Alive (10 s)Infant
(MBEN)
NoThyroid carcinomaNone
Guerrini-Rousseau et al 31 Alive (30 s)Infant
(classic)
Yes (CSI)BCCMeningioma>20
Guerrini-Rousseau et al 31 Alive (10 s)Infant
(desmoplastic)
NoHamartomaNone
Ogden et al 39 Alive (30 s)InfantYes (CSI)Bilateral ovarian leiomyosarcomaBCC
Meningioma
>100
Present reportAlive (20 s)InfantNoBilateral ovarian stromal tumourNone
Present reportAlive
(childhood)
Infant
(desmoplastic)
NoOvarian fibromaControlateral ovarian fibromaNone
Present reportAlive (10 s)InfantYes (CSI)MeningiomaMeningiomaNone
Present reportAlive (20 s)Infant
(MBEN)
Yes (CSI)MeningiomaOvarian fibrosarcoma
Thyroid carcinoma
None
  • Age range at last follow-up (2.2–37 years), age range at MB onset (0.5–2.5 years), age range at diagnosis of the other tumours (7–35 years)

  • AML, acute myeloid leukaemia; BCC, basal cell carcinoma; CSI, craniospinal radiotherapy; MB, medulloblastoma; MBEN, medulloblastoma with extensive nodularity; NA, not available; PF, posterior fossa; RT, radiotherapy.