Clinical signs of Werner syndrome in seven previously reported cases
| Registry# | EN1010 | PD1010 | BIA1010 | BIA1020 | SILV1010 | CB4 | WV |
| Age at evaluation (years) | 42 | 42 | 45 | 38 | 68 | 40s | 40 |
| Cardinal signs | |||||||
| Cataracts | Y | Y | Y | Y | Y* | Y | Y |
| Skin and facial feature | Y | Y | Y | Y | N | Y | Y |
| Short stature | N | Y | Y | Y | N | Y | Y |
| Greying or loss of hair | Y | Y | Y | Y | Y | Y | Y |
| Parental consanguinity or affected sibs | N | N | Y | Y | Y | N | NA |
| Further signs and symptoms | |||||||
| Diabetes mellitus | N | Y | Y | Y | Y | Y | N |
| Hypogonadism | N | NA | Y | Y | NA | NA | Y |
| Osteoporosis | Y | Y | Y | Y | NA | NA | Y |
| Osteosclerosis | N | NA | Y | NA | NA | NA | NA |
| Soft tissue calcification | N | N | Y | Y | Y | Y | Y |
| Atherosclerosis | N | NA | Y | NA | NA | Y | NA |
| Neoplasms | N | NA | Y | NA | Y | N | NA |
| Voice change | Y | Y | Y | Y | Y | Y | Y |
| Flat feet | N | N | Y | Y | Y | Y | NA |
| Werner syndrome diagnostic criteria | Possible | Possible | Definite | Definite | Possible | Probable | Probable |
*Unilateral cataract.
N, no; NA, not available; Y, yes.