Variables | Univariate analysis | Multivariate analysis | ||
HR (95% CI) | P value | HR (95% CI) | P value | |
Generation (4 and 3 vs 2) | 2.590 (1.990 to 3.372) | <0.001 | 2.901 (2.213 to 3.804) | <0.001 |
Mutation (truncating mutation vs missense mutation) | 1.280 (1.026 to 1.596) | 0.029 | 1.204 (0.899 to 1.613) | 0.212 |
Classification (VHL type 2 vs VHL type 1) | 1.159 (0.855 to 1.572) | 0.341 | ||
Sex (female vs male) | 0.984 (0.787 to 1.232) | 0.891 | ||
Mutation region | 0.042 | 0.014 | ||
Exon 2 vs exon 1 | 1.368 (0.975 to 1.919) | 1.406 (0.951 to 2.077) | ||
Exon 3 vs exon 1 | 1.318 (0.995 to 1.745) | 1.555 (1.169 to 2.069) | ||
Other vs exon 1 | 1.469 (1.081 to 1.996) | 1.442 (0.994 to 2.092) |
Significant p values (p<0.05) are bolded.
VHL, von Hippel-Lindau.