Table 1

Genotype–phenotype association analysis for 17q12 microdeletions (n=10) and microduplications (n=100) in participants of European ancestry in the UK Biobank (continuous traits)

Phenotype	Deletions				Duplications
Phenotype	Beta	SE	95% CI	P value	Beta	SE	95% CI	P value
eGFR	−1.91	0.27	−2.18 to −1.64	3×10⁻¹²	−0.87	0.08	−1.04 to −0.71	6×10⁻²⁵
ACR	0.45	0.30	−0.14 to 1.04	1×10⁻¹	0.40	0.10	0.21 to 0.59	4×10⁻⁵
Urea	1.84	0.31	1.23 to 2.45	3×10⁻⁹	0.68	0.10	0.49 to 0.87	1×10⁻¹²
Total protein	−0.27	0.32	−0.90 to 0.35	4×10⁻¹	0.36	0.10	0.16 to 0.56	3×10⁻⁴
HbA1c	1.26	0.28	0.71 to 1.81	7×10⁻⁶	0.11	0.09	−0.07 to 0.29	3×10⁻¹
CRP	−0.47	0.31	−1.08 to 0.14	1×10⁻¹	0.44	0.10	0.25 to 0.63	4×10⁻⁶
ALP	1.52	0.29	0.95 to 2.10	2×10⁻⁷	0.07	0.09	−0.11 to 0.25	4×10⁻¹
AST	0.83	0.31	0.22 to 1.43	7×10⁻³	0.21	0.10	0.03 to 0.40	3×10⁻²
ALT	1.15	0.30	0.55 to 1.74	2×10⁻⁴	0.03	0.09	−0.16 to 0.21	8×10⁻¹
GGT	0.81	0.29	0.24 to 1.38	5×10⁻³	0.09	0.09	−0.09 to 0.26	3×10⁻¹
FI	−0.30	0.43	−1.15 to 0.54	5×10⁻¹	−0.59	0.16	−0.91 to −0.27	3×10⁻⁴
Years in education	−0.85	0.30	−1.44 to −0.27	4×10⁻³	−0.32	0.10	−0.51 to −0.13	8×10⁻⁴
Job class	0.64	0.49	−0.32 to 1.61	2×10⁻¹	0.53	0.13	0.28 to 0.79	5×10⁻⁵
Income	−1.15	0.35	−1.82 to −0.47	9×10⁻⁴	−0.23	0.10	−0.44 to −0.03	2×10⁻²
TDI	0.73	0.30	0.15 to 1.32	1×10⁻²	0.24	0.10	0.05 to 0.43	9×10⁻³
Qualifications	−0.86	0.30	−1.45 to −0.27	4×10⁻³	−0.29	0.10	−0.48 to −0.11	2×10⁻³

See online supplemental table 1 for phenotype details.
ACR, urinary albumin creatinine ratio; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; beta, regression coefficient; CRP, C reactive protein; eGFR, estimated glomerular filtration rate (mL/min/1.73 m²; Chronic Kidney Disease Epidemiology Collaboration Creatinine-Cystatin 2012); FI, fluid intelligence; GGT, gamma glutamyl transferase; HbA1c, glycated haemoglobin; TDI, Townsend Deprivation Index.