Table 2

Risk of epithelial ovarian cancer in relatives of ovarian cancer probands versus relatives of controls in the Utah Population Database (1966–2016)

Proband typeFRR of ovarian cancer among FDRs of probands vs controlsFRR of ovarian cancer among SDRs of probands vs controlsFRR of ovarian cancer among TDRs of probands vs controls
Case FDRs (% matching proband histotype)
(n=11 197)
Control FDRs (% matching proband histotype)
(n=117 591)
FRR*
(95% CI)
Case SDRs (% matching proband histotype)
(n=32 524)
Control SDRs (% matching proband histotype)
(n=347 069)
FRR*
(95% CI)
Case TDRs (% matching proband histotype)
(n=86 059)
Control TDRs (% matching proband histotype)
(n=895 048)
FRR*
(95% CI)
All EOC1207331.68
(1.39 to 2.04)
20513841.51
(1.30 to 1.75)
47535741.34
(1.20 to 1.48)
HGSC56 (62.5)372 (51.6)1.45
(1.10 to 1.91)
110 (66.4)660 (51.1)1.66
(1.38 to 1.99)
241 (50.2)1684 (49.8)1.41
(1.25 to 1.58)
EC12 (0)74 (9.5)1.65
(0.94 to 2.90)
18 (0)126 (6.3)1.30
(0.87 to 1.92)
34 (5.9)310 (11.3)1.15
(0.92 to 1.44)
CCC† (0)27 (3.7)1.19
(0.42 to 3.32)
† (0)47 (2.1)0.91
(0.42 to 1.96)
16 (0)101 (4.0)1.55
(1.09 to 2.22)
MC† (40.0)60 (13.3)1.75
(0.99 to 3.10)
13 (15.4)123 (14.6)1.60
(1.08 to 2.37)
34 (2.9)344 (7.0)1.37
(1.10 to 1.71)
LGSC† (N/A)† (0)† (0)28 (0)0.79
(0.25 to 2.53)
† (0)64 (1.6)1.08
(0.66 to 1.75)
Other epithelial39 (38.4)194 (29.9)2.07
(1.51 to 2.84)
60 (23.3)400 (32.5)1.72
(1.39 to 2.14)
142 (25.4)1071 (32.7)1.48
(1.30 to 1.68)
  • ‘Other epithelial’: an amalgamation of carcinoma not otherwise specified, mixed tumours, carcinosarcoma and malignant Brenner.

  • *Results were generated using competing risk Cox proportional hazards models with censoring at death, bilateral oophorectomy or loss to follow-up, and adjustment for birth year, born in Utah, race, ethnicity, ever parous, number of live births, births outside of Utah, ever unilateral oophorectomy, ever unilateral salpingectomy, ever bilateral salpingectomy, ever tubal ligation and ever pelvic surgery not otherwise specified.

  • †Consistent with the Utah Department of Health confidentiality policies, we have masked low counts (n<11) and any counts that could be used to re-create the low counts.

  • ‡Model does not converge.

  • CCC, clear cell carcinoma; EC, endometrioid carcinoma; EOC, epithelial ovarian cancer; FDR, first-degree relative; FRR, familial relative risk; HGSC, high-grade serous carcinoma; LGSC, low-grade serous carcinoma; MC, mucinous carcinoma; N/A, Not applicable; SDR, second-degree relative; TDR, third-degree relative.