Univariate and multivariate analysis for risk factors of overall survival
| Variables | Univariate analysis | Multivariate analysis | ||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Generation (4 and 3 vs 2) | 1.377 (0.668 to 2.836) | 0.386 | ||
| Mutation (truncating mutation vs missense mutation) | 1.829 (1.096 to 3.052) | 0.021 | 1.435 (0.815 to 2.526) | 0.211 |
| Classification (VHL type 2 vs VHL type 1) | 0.253 (0.079 to 0.807) | 0.020 | 0.420 (0.126 to 1.402) | 0.159 |
| Sex (female vs male) | 0.881 (0.526 to 1.477) | 0.632 | ||
| Mutation region | 0.550 | |||
| Exon 2 vs exon 1 | 1.052 (0.499 to 2.217) | |||
| Exon 3 vs exon 1 | 0.654 (0.319 to 1.341) | |||
| Other vs exon 1 | 1.185 (0.603 to 2.327) | |||
| Onset age (≤28 vs >28) | 1.821 (1.051 to 3.154) | 0.033 | 1.490 (0.831 to 2.671) | 0.181 |
| First symptom (haemangioblastoma vs abdomen) | 2.908 (1.495 to 5.653) | 0.002 | 2.273 (1.142 to 4.524) | 0.019 |
Significant p values (p<0.05) are bolded.
VHL, von Hippel-Lindau.