Table 5

Univariate and multivariate analysis for risk factors of CHB-specific survival

VariablesUnivariate analysisMultivariate analysis
HR (95% CI)P valueHR (95% CI)P value
Generation (4 and 3 vs 2)1.413 (0.655 to 3.047)0.378
Mutation (truncating mutation vs missense mutation)1.760 (0.979 to 3.165)0.056
Classification (VHL type 2 vs VHL type 1)0.110 (0.015 to 0.800)0.0290.116 (0.027 to 1.485)0.116
Sex (female vs male)0.920 (0.511 to 1.657)0.780
Mutation region0.339
 Exon 2 vs exon 11.030 (0.443 to 2.397)
 Exon 3 vs exon 10.480 (0.196 to 1.175)
 Other vs exon 11.176 (0.559 to 2.475)
Onset age (≤28 vs >28)1.672 (0.904 to 3.095)0.104
First symptom (haemangioblastoma vs abdomen)6.742 (2.408 to 18.877)<0.0015.394 (1.910 to 15.232)0.001
  • Significant p values (p<0.05) are bolded.

  • CHB, central nervous system haemangioblastoma; VHL, von Hippel-Lindau.