Table 3

Univariate and multivariate analysis for age-related risk

VariablesUnivariate analysisMultivariate analysis
HR (95% CI)P valueHR (95% CI)P value
Generation (4 and 3 vs 2)2.590 (1.990 to 3.372)<0.0012.901 (2.213 to 3.804)<0.001
Mutation (truncating mutation vs missense mutation)1.280 (1.026 to 1.596)0.0291.204 (0.899 to 1.613)0.212
Classification (VHL type 2 vs VHL type 1)1.159 (0.855 to 1.572)0.341
Sex (female vs male)0.984 (0.787 to 1.232)0.891
Mutation region0.0420.014
 Exon 2 vs exon 11.368 (0.975 to 1.919)1.406 (0.951 to 2.077)
 Exon 3 vs exon 11.318 (0.995 to 1.745)1.555 (1.169 to 2.069)
 Other vs exon 11.469 (1.081 to 1.996)1.442 (0.994 to 2.092)
  • Significant p values (p<0.05) are bolded.

  • VHL, von Hippel-Lindau.