Univariate and multivariate logistic regression analyses for identifying the risk factors for the development of severe scoliosis in patients with pathogenic or likely pathogenic FBN1 variants
| Univariate analysis | Multivariate analysis | |||
| OR (95% CI) | P value* | OR (95% CI) | P value* | |
| Sex | 0.02 | 0.01 | ||
| Female | 2.01 (1.11 to 3.73) | 2.24 (1.21 to 4.27) | ||
| Male | Reference | Reference | ||
| Type of FBN1 variants | 0.02 | 0.007 | ||
| PTV | 2.03 (1.13 to 3.73) | 2.30 (1.25 to 4.33) | ||
| Non-PTV | Reference | Reference | ||
| Location of FBN1 variants | 0.01 | 0.007 | ||
| Neonatal region (exons 25–33) | 2.81 (1.28 to 6.00) | 3.11 (1.38 to 6.88) | ||
| Other regions | Reference | Reference | ||
*P<0.05.
PTV, protein-truncating variant.