Table 2

Percentage of women falling in different risk categories by status of PV in one of the high-risk or intermediate-risk genes included in the model and family history of cancer

PV status	Family history	Risk categories	Lifetime risk			Risk to age 50			Ref fig.
PV status	Family history	Risk categories	RF	PRS	RF and PRS	RF	PRS	RF and PRS	Ref fig.
Untested	NA	Population	99.9	100.0	99.4	100.0	100.0	100.0	Figure 2A,C and online supplemental figure S2A,C
		Moderate	0.1	0.0	0.6	0.0	0.0	0.0
		High	0.0	0.0	0.0	0.0	0.0	0.0
	M 50	Population	59.1	61.8	61.7	100.0	100.0	100.0	Figure 2B,D and online supplemental figure S2B,D
		Moderate	40.3	38.2	37.1	0.0	0.0	0.0
		High	0.6	0.0	1.2	0.0	0.0	0.0
BRCA1	NA	Population	0.0	0.0	0.0	0.0	0.0	0.3	Figure 3A and online supplemental figure S3A
		Moderate	0.0	0.0	0.0	1.5	0.1	4.1
		High	100.0	100.0	100.0	98.5	99.9	95.6
	M 50	Population	0.0	0.0	0.0	0.0	0.0	0.0	Figure 3B and online supplemental figure S3B
		Moderate	0.0	0.0	0.0	0.0	0.0	0.2
		High	100.0	100.0	100.0	100.0	100.0	99.8
BRCA2	NA	Population	1.6	0.1	4.7	100.0	100.0	99.9	Figure 3C and online supplemental figure S3C
		Moderate	42.8	37.7	42.3	0.0	0.0	0.1
		High	55.6	62.2	52.9	0.0	0.0	0.0
	M 50	Population	0.0	0.0	0.1	95.9	99.9	95.3	Figure 3D and online supplemental figure S3D
		Moderate	1.9	0.1	4.7	4.0	0.1	4.5
		High	98.1	99.9	95.3	0.0	0.0	0.2
RAD51D	NA	Population	0.6	0.0	2.1	100.0	100.0	99.8	Figure 3E and online supplemental figure S3E
		Moderate	24.5	18.3	30.8	0.0	0.0	0.2
		High	75.0	81.7	67.1	0.0	0.0	0.0
	M 50	Population	0.0	0.0	0.0	93.5	99.6	92.6	Figure 3F and online supplemental figure S3F
		Moderate	0.6	0.0	2.0	6.3	0.4	7.0
		High	99.4	100.0	98.0	0.2	0.0	0.4
RAD51C	NA	Population	1.8	0.1	4.9	99.8	100.0	99.3	Figure 3G and online supplemental figure S3G
		Moderate	44.4	39.3	43.1	0.2	0.0	0.7
		High	53.7	60.6	52.0	0.0	0.0	0.0
	M 50	Population	0.0	0.0	0.1	85.8	96.2	85.0	Figure 3H and online supplemental figure S3H
		Moderate	2.0	0.1	5.0	13.6	3.8	13.7
		High	98.0	99.9	95.0	0.6	0.0	1.3
BRIP1	NA	Population	43.6	34.0	45.7	100.0	100.0	99.7	Figure 3I and online supplemental figure 3I
		Moderate	52.3	65.0	47.4	0.0	0.0	0.3
		High	4.1	1.0	6.9	0.0	0.0	0.0
	M 50	Population	2.1	0.1	4.8	93.0	99.3	91.4	Figure 3J and online supplemental figure 3J
		Moderate	43.5	38.9	44.5	6.8	0.7	8.1
		High	54.5	61.1	50.7	0.3	0.0	0.5

The ‘population’ risk category is defined as lifetime risk of <5% and risk to age 50 of <3%. ‘Moderate’ risk category is defined as a lifetime risk of 5% or greater but less than 10% and a risk to age 50 of 3% or greater but less than 5%. ‘High’ risk category is defined as a lifetime risk of 10% or greater and a risk to age 50 of 5% or greater. The population lifetime risk is 1.8%, and the population risk to age 50 is 0.27%
EOC, epithelial tubo-ovarian cancer; M 50, mother diagnosed with EOC at age 50; NA, unknown family history; PV, pathogenic variant.